help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eastman, R. C.
Right arrow Articles by Roth, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eastman, R. C.
Right arrow Articles by Roth, J.

Journal of Clinical Endocrinology & Metabolism, Vol 71, 1602-1610, Copyright © 1990 by Endocrine Society

ARTICLES

Brain glucose metabolism in noninsulin-dependent diabetes mellitus: a study in Pima Indians using positron emission tomography during hyperinsulinemia with euglycemic glucose clamp

RC Eastman, RE Carson, MR Gordon, GW Berg, S Lillioja, SM Larson and J Roth
Department of Medicine, Georgetown University School of Medicine, Washington, D.C. 20007.

To determine whether insulin or noninsulin-dependent diabetes mellitus affects brain glucose metabolism, brain glucose utilization was studied in the basal state and during hyperinsulinemic euglycemic glucose clamps in nondiabetic and diabetic Pima Indians by positron emission tomography with 2-[18F]fluoro-2-deoxy-D-glucose (18FDG). Glucose utilization in 75 brain areas was determined by analysis of single scans and by least squares estimation of the rate parameters for the FDG model; these data were compared to results in normal caucasian volunteers. No effect of ethnicity or diabetic status on brain glucose utilization was observed. During the hyperinsulinemic clamps (mean insulin, 11,708 +/- 3,026 pmol/L), clearance of 18FDG from blood was accelerated, and accumulation of brain radioactivity was reduced. However, glucose utilization by the brain was identical to results during sham glucose clamps (mean insulin, 204 +/- 56 pmol/L) performed in the same patients. During the studies with hyperinsulinemia, k4 (representing loss of tissue radioactivity) was increased in most brain areas (mean increase, 0.0031 +/- 0.0018 min-1; P less than 0.02). The possible mechanisms for this effect are multiple, and the physiological significance, if any, is unknown. Further studies of the effects of insulin on brain glucose metabolism are needed.


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
O. Tschritter, H. Preissl, A. M. Hennige, M. Stumvoll, K. Porubska, R. Frost, H. Marx, B. Klosel, W. Lutzenberger, N. Birbaumer, et al.
The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: A magnetoencephalographic study
PNAS, August 8, 2006; 103(32): 12103 - 12108.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
E. R. Seaquist, G. S. Damberg, I. Tkac, and R. Gruetter
The Effect of Insulin on In Vivo Cerebral Glucose Concentrations and Rates of Glucose Transport/Metabolism in Humans
Diabetes, October 1, 2001; 50(10): 2203 - 2209.
[Abstract] [Full Text]

Home page
 DiabetesHome page
S. A. Segel, C. G. Fanelli, C. S. Dence, J. Markham, T. O. Videen, D. S. Paramore, W. J. Powers, and P. E. Cryer
Blood-to-Brain Glucose Transport, Cerebral Glucose Metabolism, and Cerebral Blood Flow Are Not Increased After Hypoglycemia
Diabetes, August 1, 2001; 50(8): 1911 - 1917.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1990 by The Endocrine Society