Journal of Clinical Endocrinology & Metabolism, Vol 71, 1556-1560, Copyright © 1990 by Endocrine Society

ARTICLES

The circadian rhythm of intact parathyroid hormone-(1-84): temporal correlation with prolactin secretion in normal men

FC Logue, WD Fraser, DS O'Reilly, DA Cameron, AJ Kelly and GH Beastall
Institute of Biochemistry, Royal Infirmary, Glasgow, United Kingdom.

Serum PTH-(1-84), PRL, and adjusted calcium concentrations were determined at 30-min intervals for a 24-h period in six normal adult men. PTH-(1-84) and PRL both exhibited two peaks of increased secretion [1600-1900 and 0200-0600 h for PTH-(1-84); 2000-2200 and 0400-0800 h for PRL]. For each subject there was a striking similarity in the magnitude of secretion of the two hormones and a consistent temporal relationship. Thus, the maximum correlation coefficients of 0.62-0.83 were obtained for the six subjects when the PRL surge lagged that of PTH-(1-84) by 0.5-3.5 h. In contrast, the correlation between PTH-(1- 84) and adjusted calcium was weaker (r = -0.36 to -0.66) and showed no consistent temporal relationship (0.0-10.5 h). These data support the concept of higher center control of PTH-(1-84) secretion with the possible involvement of factors common to the control of PRL secretion.

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