Journal of Clinical Endocrinology & Metabolism, Vol 71, 1416-1420, Copyright © 1990 by Endocrine Society

ARTICLES

Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein

CA Landis, G Harsh, J Lyons, RL Davis, F McCormick and HR Bourne
Department of Medicine, University of California, San Francisco 94143.

Activating mutations in the gene for the alpha-chain of Gs, the stimulatory regulator of adenylyl cyclase, have been identified in human GH-secreting pituitary tumors. Using the polymerase chain reaction and allele-specific oligonucleotide hybridization, we screened 25 GH-secreting tumors for the presence of the activating mutations. We also reviewed the clinical charts of the patients from whom the tumors were removed. Of 25 tumors, 10 (40%) contained activating mutations. Patients in the mutation-positive group came to surgery with smaller tumors and had lower GH levels. The activating mutations identify a subgroup of GH-secreting pituitary tumors that probably arise from a shared oncogenic mechanism.

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