Journal of Clinical Endocrinology & Metabolism, Vol 71, 1127-1130, Copyright © 1990 by Endocrine Society

ARTICLES

Reproducibility of growth hormone testing procedures: a comparison between 24-hour integrated concentration and pharmacological stimulation

Z Zadik, SA Chalew, Z Gilula and AA Kowarski
Pediatric Endocrine Unit, Kaplan Hospital, Rehovot, Israel.

The purpose of this study was to compare the reproducibility of two approaches to the evaluation of GH secretion: the integrated concentration of GH (IC-GH), a physiological test of GH secretion, and pharmacological stimulation tests. IC-GH was determined in 40 poorly growing children twice within 4 weeks. The first and second IC-GH were highly correlated r = 0.859, P less than 0.001. One hundred and thirteen poorly growing children underwent pharmacological GH stimulation tests twice within 6 weeks. A moderate correlation was found between the first and second pharmacological test r = 0.524, P less than 0.01. Among the three pharmacological stimuli studied, clonidine (n = 81) had the highest reproducibility followed by arginine (n = 20), and insulin (n = 12). We conclude that IC-GH is more consistently reproducible than the GH response to repeated pharmacological stimulation.

This article has been cited by other articles:

				Z. Zadik, T. Sinai, A. Zung, and R. Reifen Effect of Nutrition on Growth in Short Stature Before and During Growth-Hormone Therapy Pediatrics, July 1, 2005; 116(1): 68 - 72. [Abstract] [Full Text] [PDF]

				H K Gleeson and S M Shalet The impact of cancer therapy on the endocrine system in survivors of childhood brain tumours Endocr. Relat. Cancer, December 1, 2004; 11(4): 589 - 602. [Abstract] [Full Text] [PDF]

				H. K. Gleeson, H. R. Gattamaneni, L. Smethurst, B. M. Brennan, and S. M. Shalet Reassessment of Growth Hormone Status Is Required at Final Height in Children Treated with Growth Hormone Replacement after Radiation Therapy J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 662 - 666. [Abstract] [Full Text] [PDF]

				J. J. Bell and K. Dana Lack of Correlation Between Growth Hormone Provocative Test Results and Subsequent Growth Rates During Growth Hormone Therapy Pediatrics, August 1, 1998; 102(2): 518 - 520. [Abstract] [Full Text]

				S. M. Shalet, A. Toogood, A. Rahim, and B. M. D. Brennan The Diagnosis of Growth Hormone Deficiency in Children and Adults Endocr. Rev., April 1, 1998; 19(2): 203 - 223. [Abstract] [Full Text]

				J.-C. Carel, J.-P. Tresca, M. Letrait, J.-L. Chaussain, Y. Lebouc, J.-C. Job, and J. Coste Growth Hormone Testing for the Diagnosis of Growth Hormone Deficiency in Childhood: A Population Register-Based Study J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2117 - 2121. [Abstract] [Full Text] [PDF]

				M. Tauber, P. Moulin, C. Pienkowski, B. Jouret, and P. Rochiccioli Growth Hormone (GH) Retesting and Auxological Data in 131 GH-Deficient Patients after Completion of Treatment J. Clin. Endocrinol. Metab., February 1, 1997; 82(2): 352 - 356. [Abstract] [Full Text] [PDF]