help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roth, K. A.
Right arrow Articles by Krause, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roth, K. A.
Right arrow Articles by Krause, J. E.

Journal of Clinical Endocrinology & Metabolism, Vol 71, 1089-1095, Copyright © 1990 by Endocrine Society

ARTICLES

Substance-P is present in a subset of thyrotrophs in the human pituitary

KA Roth and JE Krause
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.

Substance-P immunoreactivity and tachykinin-like peptides are present in the pituitary gland of several mammalian species. In humans, however, the biochemical nature and cellular localization of pituitary substance-P has not been defined. We report here that substance-P- immunoreactive material is present in low concentrations in both the anterior and posterior lobes of the human pituitary gland. Gel chromatography and reverse phase high performance liquid chromatography indicate that the majority of the substance-P immunoreactivity in human pituitaries elutes as authentic substance-P and its oxidized derivative. Immunohistochemical studies showed substance-P- immunoreactive fibers and terminals in the posterior pituitary gland and occasional substance-P-immunoreactive cell bodies in the anterior lobe. The substance-P-immunoreactive cells were found to colocalize with a small subpopulation of TSH beta-immunoreactive cells (thyrotrophs). Substance-P immunoreactivity was also found in a pituitary microadenoma that contained numerous TSH beta-immunoreactive cells. These studies indicate that substance-P is present in the human pituitary gland, and they suggest a relationship between substance-P and thyroid function.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
H. Satake, M. Ogasawara, T. Kawada, K. Masuda, M. Aoyama, H. Minakata, T. Chiba, H. Metoki, Y. Satou, and N. Satoh
Tachykinin and Tachykinin Receptor of an Ascidian, Ciona intestinalis: EVOLUTIONARY ORIGIN OF THE VERTEBRATE TACHYKININ FAMILY
J. Biol. Chem., December 17, 2004; 279(51): 53798 - 53805.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
W. Dong and R. Day
Gene Expression of Proprotein Convertases in Individual Rat Anterior Pituitary Cells and Their Regulation in Corticotrophs Mediated by Glucocorticoids
Endocrinology, January 1, 2002; 143(1): 254 - 262.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
K. A. Roth, J. W. Brenner, L. A. Selznick, M. Gokden, and R. G. Lorenz
Enzyme-based Antigen Localization and Quantitation in Cell and Tissue Samples (Midwestern Assay)
J. Histochem. Cytochem., December 1, 1997; 45(12): 1629 - 1642.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Iino, H. Sasano, Y. Oki, N. Andoh, R.-W. Shin, T. Kitamoto, K. Totsune, K. Takahashi, H. Suzuki, H. Nagura, et al.
Urocortin Expression in Human Pituitary Gland and Pituitary Adenoma
J. Clin. Endocrinol. Metab., November 1, 1997; 82(11): 3842 - 3850.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1990 by The Endocrine Society