| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 71, 963-969, Copyright © 1990 by Endocrine Society
ARTICLES |
SG Korenman, JE Morley, AD Mooradian, SS Davis, FE Kaiser, AJ Silver, SP Viosca and D Garza
Department of Medicine, University of California, Los Angeles 90024.
The relation of the reproductive endocrine system to impotence in older men was examined by measuring the concentrations of testosterone (T), bioavailable testosterone (BT), LH, and PRL and body mass index (BMI) in 57 young controls (YC), 50 healthy potent older controls attending a health fair (HF), and 267 impotent patients (SD). The SD and HF had markedly reduced mean T and BT values compared to YC. When adjusted for age and BMI there was no difference in BT between potent and impotent older men. The percent BT was much higher in YC than in the older groups. While the percent BT rose significantly with increased T in YC, it was inversely related to T in the older subjects, suggesting that increased sex hormone-binding globulin binding was a primary event leading to a low BT. Forty-eight percent of HF and 39% of SD were hypogonadal, as defined by a mean BT of 2.5 SD or more below the mean of YC (less than or equal to 2.3 nmol/L). Ninety percent of these had LH values in the normal range, suggesting hypothalamic-pituitary dysfunction. Thirty-four SD and six each of YC and older control volunteers (OC) underwent GnRH testing. Older subjects showed impaired responsiveness to GnRH compared to YC. A low basal LH level correlated very highly with hyporesponsiveness to GnRH. Thus, secondary hypogonadism and impotence are two common, independently distributed conditions of older men.
This article has been cited by other articles:
 |
|
 |
|
  M. Wald, M. Miner, and A. D. Seftel State of the Art Reviews: Male Menopause: Fact or Fiction? American Journal of Lifestyle Medicine, April 1, 2008; 2(2): 132 - 141. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Giton, S. Urien, C. Born, J. Tichet, J. Guechot, J. Callebert, F. Bronsard, J. P. Raynaud, and J. Fiet Determination of Bioavailable Testosterone [Non Sex Hormone Binding Globulin (SHBG)-Bound Testosterone] in a Population of Healthy French Men: Influence of Androstenediol on Testosterone Binding to SHBG Clin. Chem., December 1, 2007; 53(12): 2160 - 2168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bhasin, G. R. Cunningham, F. J. Hayes, A. M. Matsumoto, P. J. Snyder, R. S. Swerdloff, and V. M. Montori Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes: An Endocrine Society Clinical Practice Guideline J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 1995 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Giton, J. Fiet, J. Guechot, F. Ibrahim, F. Bronsard, D. Chopin, and J.-P. Raynaud Serum Bioavailable Testosterone: Assayed or Calculated? Clin. Chem., March 1, 2006; 52(3): 474 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Kaufman and A. Vermeulen The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications Endocr. Rev., October 1, 2005; 26(6): 833 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. McDermott and C. H. Walsh Hypogonadism in Hereditary Hemochromatosis J. Clin. Endocrinol. Metab., April 1, 2005; 90(4): 2451 - 2455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Asthana, S. Bhasin, R. N. Butler, H. Fillit, J. Finkelstein, S. M. Harman, L. Holstein, S. G. Korenman, A. M. Matsumoto, J. E. Morley, et al. Masculine Vitality: Pros and Cons of Testosterone in Treating the Andropause J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2004; 59(5): M461 - M465. [Full Text] [PDF]
|
|
|
|
|
|
B. Z. Leder, J. L. Rohrer, S. D. Rubin, J. Gallo, and C. Longcope Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testosterone Levels J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1174 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ojumu and A. S. Dobs Is Hypogonadism a Risk Factor for Sexual Dysfunction? J Androl, November 1, 2003; 24(6_suppl): S46 - S51. [Full Text] [PDF]
|
|
|
|
|
|
R. Luboshitzky, Z. Shen-Orr, and P. Herer Middle-Aged Men Secrete Less Testosterone at Night Than Young Healthy Men J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3160 - 3166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Kenny, S. Bellantonio, C. A. Gruman, R. D. Acosta, and K. M. Prestwood Effects of Transdermal Testosterone on Cognitive Function and Health Perception in Older Men With Low Bioavailable Testosterone Levels J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2002; 57(5): M321 - 325. [Abstract] [Full Text]
|
|
|
|
|
|
P. Kunelius, O. Lukkarinen, M. L. Hannuksela, O. Itkonen, and J. S. Tapanainen The Effects of Transdermal Dihydrotestosterone in the Aging Male: A Prospective, Randomized, Double Blind Study J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1467 - 1472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Matsumoto Andropause: Clinical Implications of the Decline in Serum Testosterone Levels With Aging in Men J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2002; 57(2): M76 - 99. [Full Text]
|
|
|
|
|
|
J. E. Morley Decreased Food Intake With Aging J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2001; 56(90002): 81 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Kandeel, V. K. T. Koussa, and R. S. Swerdloff Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment Endocr. Rev., June 1, 2001; 22(3): 342 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Morley Editorial: Andropause: Is It Time for the Geriatrician to Treat It? J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2001; 56(5): 263M - 265. [Full Text]
|
|
|
|
|
|
A. M. Kenny, K. M. Prestwood, C. A. Gruman, K. M. Marcello, and L. G. Raisz Effects of Transdermal Testosterone on Bone and Muscle in Older Men With Low Bioavailable Testosterone Levels J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2001; 56(5): 266M - 272. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Harman, E. J. Metter, J. D. Tobin, J. Pearson, and M. R. Blackman Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 724 - 731. [Abstract] [Full Text]
|
|
|
|
|
|
A. W. van den Beld, F. H. de Jong, D. E. Grobbee, H. A. P. Pols, and S. W. J. Lamberts Measures of Bioavailable Serum Testosterone and Estradiol and Their Relationships with Muscle Strength, Bone Density, and Body Composition in Elderly Men J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3276 - 3282. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Kenny, K. M. Prestwood, K. M. Marcello, and L. G. Raisz Determinants of Bone Density in Healthy Older Men With Low Testosterone Levels J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2000; 55(9): 492M - 497. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Veldhuis, A. Iranmanesh, M. Godschalk, and T. Mulligan Older Men Manifest Multifold Synchrony Disruption of Reproductive Neurohormone Outflow J. Clin. Endocrinol. Metab., April 1, 2000; 85(4): 1477 - 1486. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. C Gould, R. Petty, and H. S Jacobs For and against: The male menopause---does it exist? • For • Against BMJ, March 25, 2000; 320(7238): 858 - 861. [Full Text]
|
|
|
|
|
|
E. Barrett-Connor, D. Goodman-Gruen, and B. Patay Endogenous Sex Hormones and Cognitive Function in Older Men J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3681 - 3685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bergendahl, J. A. Aloi, A. Iranmanesh, T. M. Mulligan, and J. D. Veldhuis Fasting Suppresses Pulsatile Luteinizing Hormone (LH) Secretion and Enhances Orderliness of LH Release in Young but Not Older Men J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 1967 - 1975. [Abstract] [Full Text]
|
|
|
|
|
|
R. R. Hajjar, F. E. Kaiser, and J. E. Morley Outcomes of Long-Term Testosterone Replacement in Older Hypogonadal Males: A Retrospective Analysis J. Clin. Endocrinol. Metab., November 1, 1997; 82(11): 3793 - 3796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Kurland, C. J. Rosen, F. Cosman, D. McMahon, F. Chan, E. Shane, R. Lindsay, D. Dempster, and J. P. Bilezikian Insulin-Like Growth Factor-I in Men with Idiopathic Osteoporosis J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 2799 - 2805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Morley, F. Kaiser, W. J. Raum, H. M. Perry III, J. F. Flood, J. Jensen, A. J. Silver, and E. Roberts Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone PNAS, July 8, 1997; 94(14): 7537 - 7542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sih, J. E. Morley, F. E. Kaiser, H. M. Perry III, P. Patrick, and C. Ross Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1661 - 1667. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
