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Journal of Clinical Endocrinology & Metabolism, Vol 71, 1056-1058, Copyright © 1990 by Endocrine Society
ARTICLES |
MR Murphy, SA Checkley, JR Seckl and SL Lightman
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, England.
We examined the effect of naloxone on plasma oxytocin levels during sexual activity in men. Eight normal men took part in a double-blind, two-period, cross-over design. Mean plasma oxytocin rose to 362% of baseline values at orgasm with placebo (saline) but showed no increase with naloxone (P less than 0.01). While naloxone had no effect on heart rate or blood pressure at orgasm, a decrease in the level of subjective arousal and pleasure at orgasm was noted. We conclude that opioid receptor blockade with naloxone has an inhibitory effect on the neural pathways mediating the oxytocin response at orgasm.
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