help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Journal of Clinical Endocrinology & Metabolism Vol. 71, No. 2 433-435
doi:10.1210/jcem-71-2-433
Copyright © 1990 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GHIGO, E.
Right arrow Articles by CAMANNI, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GHIGO, E.
Right arrow Articles by CAMANNI, F.

Acute Clonidine Administration Potentiates Spontaneous Diurnal, but not Nocturnal, Growth Hormone Secretion in Normal Short Children

EZIO GHIGO, EMANUELA ARVAT, MARIO NICOLOSI, JAELE BELLONE, MARIA ROSA VALETTO, ENRICO MAZZA, ELISEO IMPERIALE, MASSIMO PROCOPIO, MARIA CRISTINA GHIGO and FRANCO CAMANNI

Department of Clinical Physiopathology, Division of Endocrinology, University of Turin Turin, Italy

Address requests for reprints to: Prof. F. Camanni, Divisione Endocrinologia, Ospedale Molinette C.so Polonia 14,10126 Torino, Italy.

It has been shown that {alpha}2-adrenoreceptor activation induced by clonidine (CLON) increases plasma GH levels in both adults and children. In this study the effects of CLON (150 µg/m2, orally) on GH secretion were studied both in the morning (from 0800–1100 h) and at night (from 2300–0200 h) in nine short children previously shown to have normal spontaneous nocturnal GH secretion. In the morning, CLON induced a GH increase higher than placebo [peak (mean ± SEM), 23.8 ± 4.3 vs. 3.4 ± 1.4 µg/L; P = 0.0001; area under curve (AUC), 624.4 ± 62.7 vs. 135.6 ± 33.3 µg/L·h; P < 0.00001]. In the night, no difference was observed between GH secretion after CLON (peak, 15.4 ± 3.2 µg/L; AUC, 562.2 ± 57.5 µg/L·h) and placebo(peak, 13.1 ± 4.7 µg/L; AUC, 497.2 ± 83.5 µg/L·h). Spontaneous GH secretion was higher during the night than in the morning (P = 0.0001), whereas nocturnal GH secretion overlapped with that in the morning after CLON. The data presented show that {alpha}2-adrenoreceptor activation is probably mediated by increased endogenous GHRH release; our results suggest that the endogenous GHRH secretion is maximally stimulated at night.

Received October 17, 1989.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1990 by The Endocrine Society