This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by PRIDDY, A. R. Articles by ELDER, M. Search for Related Content PubMed PubMed Citation Articles by PRIDDY, A. R. Articles by ELDER, M.

The Effect of Prostaglandin Synthetase Inhibitors on Human Preovulatory Follicular Fluid Prostaglandin, Thromboxane, and Leukotriene Concentrations^*

Departments of Obstetrics and Gynaecology (A.R.P., S.R.K., M.E.) and Statistics (J.M.), University Hospital of South Manchester Manchester
The Department of Obstetrics and Gynaecology, Hammersmith Hospital (M.S., L.P., M.E.) London, United Kingdom

Address requests for reprints to: Alvan Priddy, M.R.C.O.G., Department of Obstetrics and Gynaecology, University Hospital of South Manchester, West Didsbury, Manchester, M20 8LR, United Kingdom.

This study evaluates the eicosanoid concentration in luteinized unruptured follicles (LUFs) on the ovaries of patients who had been treated with inhibitors of prostaglandin synthetase. Indomethacin, bromfenac, or azapropazone (or a placebo) was administered orally to 41 women during the periovulatory period. Follicular development was monitored by serial ultrasound examinations, and the onset of ovulation was regulated by an injection of hCG. Follicular fluid was aspirated during sterilization by minilaparotomy, which was performed just before the expected time of ovulation. Prostaglandin E₂ and PGF₂ levels in the fluid were significantly reduced by indomethacin and bromfenac compared to those after placebo treatment. Bromfenac also reduced the follicular fluid leukotriene B4 level. Therefore, the development of luteinized unruptured follicles after treatment with nonsteroidal antiinflammatory drugs appears to be associated with a significant decrease in the synthesis of ovarian eicosanoids.

^* This work was supported by A.H. Robbins Ltd.

Received August 4, 1989.

This article has been cited by other articles:

				P. J. Bridges, C. M. Komar, and J. E. Fortune Gonadotropin-Induced Expression of Messenger Ribonucleic Acid for Cyclooxygenase-2 and Production of Prostaglandins E and F2{alpha} in Bovine Preovulatory Follicles Are Regulated by the Progesterone Receptor Endocrinology, October 1, 2006; 147(10): 4713 - 4722. [Abstract] [Full Text] [PDF]

				D. M. Duffy, C. L. Seachord, and B. L. Dozier An Ovulatory Gonadotropin Stimulus Increases Cytosolic Phospholipase A2 Expression and Activity in Granulosa Cells of Primate Periovulatory Follicles J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5858 - 5865. [Abstract] [Full Text] [PDF]