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Identification of Placental Human Growth Hormone as the Growth Hormone-V Gene Expression Product^*

Experimental and Clinical Endocrinology, CHU B-23, B-400 Liege; and Laboratorium uoor Microbiologie (J. V.B.) Ledeganckstraat 35, B-900 Gent, Belgium

Address requests for reprints to: Dr. Francis Frankenne, Experimental and Clinical Endocrinology, CHU B-23, B-4000 Liege, Belgium.

A GH variant of placental origin, placental GH, has recently been shown to replace pituitary GH in maternal serum during pregnancy. Besides, the GH variant (GH-V) gene has been demonstrated to be expressed in the placenta. The similarities between their known properties strongly suggest that the placental GH and the GH-V protein are the same molecular species. Here we provide final evidence that this is indeed the case by sequence analysis of both the 22K and 25K forms. Furthermore, the 25K form is shown to be glycosylated, while the 22K form is not. Both size variants of placental GH are, thus, likely to reflect the partial glycosylation of a unique pep-tidic chain.

^* This work was supported by the Science Policy Programming Department of the Prime Minister's Office and grants from the Belgian FNRS and the Region Wallonne.

Received June 15, 1989.

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