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Journal of Clinical Endocrinology & Metabolism, Vol 70, 1744-1749, Copyright © 1990 by Endocrine Society

ARTICLES

Spontaneously occurring antibodies to parathyroid hormone

M Wilkinson, A McElduff, J Wilson, P Haber, A Freeman, M Robertson and P Mathews
Department of Endocrinology, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.

A 76-yr-old female with acute pancreatitis and a normal/borderline elevated serum calcium level was found to have an elevated immunoreactive circulating PTH concentration using a C-terminal assay. This high PTH concentration misled the attending physicians and resulted, in retrospect, in an unnecessary neck exploration. When the patient's serum was examined it was found to contain a binding component that bound both C-terminal and PTH-(1-84). This binding component was not retained on a Sep-Pak column and was precipitated by antiserum directed against human immunoglobulin M. The presence of circulating anti-PTH immunoglobulin M explains the apparently high PTH concentrations measured by RIA. The antibodies occurred spontaneously. To the best of our knowledge, this phenomenon has not previously been described.




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