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Journal of Clinical Endocrinology & Metabolism Vol. 70, No. 6 1651-1653
doi:10.1210/jcem-70-6-1651
Copyright © 1990 by the Endocrine Society.
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Long Term Effects of a First Pregnancy on Serum Concentrations of Dehydroepiandrosterone Sulfate and Dehydroepiandrosterone

TIMOTHY J. A. KEY, MALCOLM C. PIKE, DENNIS Y. WANG and JOHN W. MOORE

Imperial Cancer Research Fund, Cancer Epidemiology Unit, Radcliffe Infirmary (T.J.A.K.) Oxford, 0X2 6HE United Kingdom
Department of Preventive Medicine, University of Southern California School of Medicine (M.C.P.) Los Angeles, California 90033–9987
the Imperial Cancer Research Fund, Clinical Endocrinology Laboratory, Lincoln's Inn Fields (D. Y. W., J. W.M.) London, WC2A 3PX United Kingdom

Address all correspondence and requests for reprints to: Timothy J. A. Key, Imperial Cancer Research Fund, Cancer Epidemiology Unit, Gibson Building, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE United Kingdom.

A previous paper in this journal reported that first pregnancy was followed by a marked decrease in dehydroepiandrosterone sulfate (DHAS) and dehydroepiandrosterone (DHA) levels. We report here confirmatory observations from cross-sectional measurements in 460 women. In premenopausal subjects (n = 306), the mean DHAS level was 21% lower (P = 0.005) and the mean DHA level was 32%lower (P < 0.001) in parous than in nulliparous women. Neither DHAS nor DHA was related to parity in postmenopausal women (n = 154).

Received October 30, 1989.




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