help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Journal of Clinical Endocrinology & Metabolism Vol. 70, No. 6 1568-1573
doi:10.1210/jcem-70-6-1568
Copyright © 1990 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by COLVIN, P. L.
Right arrow Articles by APPLEBAUM-BOWDEN, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by COLVIN, P. L., JR.
Right arrow Articles by APPLEBAUM-BOWDEN, D.

Differential Effects of Oral Estrone Versus 170-Estradiol on Lipoproteins in Postmenopausal Women*

PERRY L. COLVIN, JR., BRUCE J. AUERBACH, DONALD R. KORITNIK, WILLIAM R. HAZZARD and DEBORAH APPLEBAUM-BOWDEN

Departments of Internal Medicine and Comparative Medicine, Bowman Gray School of Medicine, Wake Forest University Winston-Salem, North Carolina 27103

Address all correspondence and requests for reprints to: Perry L. Colvin, Jr., M.D. Department of Internal Medicine, Bowman Gray School of Medicine, 300 South Hawthorne Road, Winston-Salem, North Carolina 27103.

Toward the definition of optimal postmenopausal estrogen replacement we compared the effects of three graduated doses of two oral estrogens, estrone sulfate and 17/3-estradiol, on the lipid profiles of two groups of six postmenopausal women. Because of metabolic interconversions equivalent serum concentrations of estrone and estradiol were produced with these regimens. However, differential effects were noted in lipoproteins. 17/3-Estradiol caused an increase in total plasma cholesterol (from 5.71 ± 0.36 to 5.99 ± 0.57 mmol/L, baseline to high dose; P < 0.02), high density lipoprotein (HDL) cholesterol (from 1.45 ± 0.15 to 1.78 ± 0.36 mmol/L; P < 0.02), HDL2 cholesterol concentration (from 0.41 ± 0.08 to 0.62 ± 0.26 mmol/ L; P < 0.01), and triglyceride concentration (from 1.09 ± 0.29 to 1.24 ± 0.30 mmol/L; P < 0.01) without affecting low density lipoprotein (LDL) cholesterol concentration. By contrast, estrone sulfate caused a decrease in total plasma cholesterol (from 6.51 ± 0.85 to 5.87 ± 0.41 mmol/L; P < 0.05) and LDL cholesterol concentration (from 4.34 ± 0.57 to 3.67 ± 0.44 mmol/L; P < 0.01) and an increase in HDL cholesterol (from 1.37 ± 0.20 to 1.50 ± 0.26 mmol/L; P < 0.05) and HDL2 cholesterol concentration (from 0.34 ± 0.18 to 0.49 ± 0.18 mmol/L; P < 0.01), but no change in total triglyceride concentration. We deduce that the differential effect of orally administered estrogens on lipoprotein metabolism in postmenopausal women may be attributed to a first pass effect on hepatic metabolism.

* This work was supported in part by NIH Grants HL-38624 and HL-38222.

Received March 13, 1989.




This article has been cited by other articles:


Home page
Arch Intern MedHome page
J. C. Krakauer and J. D. Fachnie
Gender and Lipids in Coronary Artery Disease
Arch Intern Med, September 1, 1991; 151(9): 1881 - 1881.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1990 by The Endocrine Society