help button home button Endocrine Society JCEM ENDO 08
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taylor, R. N.
Right arrow Articles by Roberts, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taylor, R. N.
Right arrow Articles by Roberts, J. M.

Journal of Clinical Endocrinology & Metabolism, Vol 70, 1285-1291, Copyright © 1990 by Endocrine Society

ARTICLES

Partial characterization of a novel growth factor from the blood of women with preeclampsia

RN Taylor, TJ Musci, RW Kuhn and JM Roberts
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco 94143-0132.

Sera obtained before delivery from women with preeclampsia contain greater mitogenic activity than sera drawn from the same women 24-48 h after parturition or sera from normal parturients. These studies describe the initial characterization of the blood-borne mitogenic factor(s) from preeclamptic women which we have named ELMER (Endogenous Ligand conferring MitogEnic Response). ELMER appears to be a unique mitogen with characteristics that are not identical to those of other known growth factors. ELMER is present in serum as an acid- and heat- labile protein, approximately 160,000 daltons in size, which is a potent mitogen for human fibroblasts but not for human endothelial cells. Its presence in plasma suggests that it is a circulating factor rather than a product of blood coagulation ex vivo. We believe that ELMER represents a potential serum marker of preeclampsia and that it may play roles in the vasospasm and proliferative vascular lesion, termed atherosis, frequently associated with the preeclamptic syndrome.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
J.-L. Vigne, J. T. Murai, B. W. Arbogast, W. Jia, S. J. Fisher, and R. N. Taylor
Elevated Nonesterified Fatty Acid Concentrations in Severe Preeclampsia Shift the Isoelectric Characteristics of Plasma Albumin
J. Clin. Endocrinol. Metab., November 1, 1997; 82(11): 3786 - 3792.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1990 by The Endocrine Society