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Androstenedione and Estrone Dynamics in Hypothyroid Women^*

Departments of Obstetrics and Gynecology and Medicine, University of Massachusetts Medical School Worcester, Massachusetts 01655

Address all correspondence and requests for reprints to: Dr. C. Longcope, Department of Obstetrics and Gynecology, S4–721, University of Massachusetts Medical School, Worcester, Massachussetts 01655.

To examine the effects of hypothyroidism on androstenedione (A) and estrone (E₁) metabolism, we infused eight women with [³H]androstenedione and [¹⁴C]estrone when they were hypothyroid and again when they were euthyroid after levo-T₄ administration. MCRs and conversion ratios were measured using concentrations of radioactivity in the blood pools of A and E₁. Peripheral aromatization was measured from the concentrations of radioactivity in the E₁ glucuronide pool in the urine. After the women were euthyroid, the MCR of A had increased in seven of eight, the MCR of E₁ increased in all eight, and peripheral aromatization had decreased in seven of eight. These findings indicate that hypothyroidism results in a decrease in the MCRs of A and E₁ and, in most subjects, an increase in peripheral aromatization of A to E₁.

^* This work was supported in part by Grants DK-18919 and DK-07302 from the NIDDK, NIH (Bethesda, MD).

Received August 23, 1989.

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