| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 70, 1007-1013, Copyright © 1990 by Endocrine Society
ARTICLES |
A Garg, A Bonanome, SM Grundy, RH Unger, NA Breslau and CY Pak
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
Transient hypercalciuria has been noted after high carbohydrate meals which is independent of dietary calcium and is probably due to impaired renal calcium reabsorption mediated by an increase in plasma insulin levels. Based on these observations, some investigators believe that long term intake of high carbohydrate diets may increase the risk of nephrolithiasis and possibly osteoporosis. Using a randomized cross- over design, we compared high carbohydrate diets (60% carbohydrate and 25% fat) with high fat diets (50% fat and 35% carbohydrate) for effects on metabolism of calcium and other minerals in eight normal subjects and eight euglycemic patients with noninsulin-dependent diabetes mellitus. All other dietary constituents, such as protein, fiber, fluid, minerals (including Ca, Mg, Na, K, and P), and caffeine intake, were kept constant. Despite higher daylong levels of plasma insulin on the high carbohydrate diets compared to the high fat diet in both normal and noninsulin-dependent diabetic subjects, no changes in daily urinary excretion of calcium or other constituents, associated with renal stone risk, were observed. Furthermore, there was no change in fractional intestinal 47Ca absorption. Although hypercalciuria may ensue transiently after high carbohydrate meals, we conclude that substitution of simple or complex carbohydrates for fats in an isocaloric manner for a longer duration does not result in significant urinary calcium loss, and therefore, high intakes of digestible carbohydrates may not increase the risk of nephrolithiasis or osteoporosis via this mechanism.
This article has been cited by other articles:
![]() |
V. Simha, J. E. Zerwekh, K. Sakhaee, and A. Garg Effect of Subcutaneous Leptin Replacement Therapy on Bone Metabolism in Patients with Generalized Lipodystrophy J. Clin. Endocrinol. Metab., November 1, 2002; 87(11): 4942 - 4945. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-S. Chung, M.-D. Lee, S.-K. Lee, H.-M. Kim, and L. A. Fitzpatrick HMG-CoA Reductase Inhibitors Increase BMD in Type 2 Diabetes Mellitus Patients J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 1137 - 1142. [Abstract] [Full Text] |
||||
![]() |
U. Nguyen Increased Urinary Calcium Excretion after Acute Aspartame Ingestion in Healthy Subjects--Authors' Response J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 384 - 384. [Full Text] |
||||
![]() |
U. N. Nguyen, G. Dumoulin, M.-T. Henriet, and J. Regnard Aspartame Ingestion Increases Urinary Calcium, But Not Oxalate Excretion, in Healthy Subjects J. Clin. Endocrinol. Metab., January 1, 1998; 83(1): 165 - 168. [Abstract] [Full Text] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |