Journal of Clinical Endocrinology & Metabolism, Vol 70, 551-553, Copyright © 1990 by Endocrine Society

ARTICLES

Identification of insulin-like growth factor-binding protein-2 (IGF-BP- 2) and a low molecular weight IGF-BP in human seminal plasma

RG Rosenfeld, H Pham, Y Oh, G Lamson and LC Giudice
Department of Pediatrics, Stanford University Medical Center, California 94305.

Three distinct binding proteins for the insulin-like growth factors (IGF-BPs) have recently had their cDNAs cloned and sequenced. We have evaluated IGF-BP expression in normal, oligospermic and azospermic human seminal plasma (SP), and have identified IGF-BP-2 in all samples. Additionally, SP contains a non-glycosylated low molecular weight IGF- BP (24K), which does not appear to be structurally or immunologically related to IGF-BP-1, -2 or -3.

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