| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Departments of Medicine (D.B., B.J.), Orthopedics (D.B., A.S., J.G.), Pharmacology (R.L., B.J.), Radiology (A.K.), and Nuclear Medicine (J.R.), University of Massachusetts Medical School Worcester, Massachusetts 01655
Address requests for reprints to: Daniel T. Baran, M.D., Department of Orthopedics, University of Massachusetts Medical Center, 55 Lake Avenue, North Worcester, Massachusetts 01655.
The effect of dietary calcium on vertebral bone mass in women is controversial. In a randomized study we have investigated the effect of dietary modification in the form of dairy products on vertebral bone mass in 30- to 42-yr-old premenopausal women over a 3-yr period. Twenty women increased their dietary calcium intake by an average of 610 mg/day (P < 0.03) for 3 yr, while 17 age- and weight-matched women served as controls. Calcium intake was monitored by 3-day diet histories and 24-h urinary calcium excretion. The consumption of the dairy products did not alter serum calcium or PTH levels or the fasting urinary calcium to creatinine ratio. Twenty-four-hour urinary calcium excretion increased by 28% (P < 0.03) in the supplemented women. Dairy product intake was accompanied by increased dietary fat intake, but there were no statistically significant changes in serum cholesterol, low density lipoprotein cholesterol, or high density lipoprotein cholesterol levels. The vertebral bone density in the women consuming increased calcium did not change over the 3-yr period (–0.4 ± 0.9%). In contrast, the vertebral bone density in the control women declined (–2.9 ± 0.8%; P < 0.001) and was significantly lower than that in the supplemented group at 30 and 36 months. The study suggests that dietary modification in the form of dairy products retards vertebral bone loss in premenopausal women. Therefore, increased calcium intake in estrogen-replete premenopausal women may prevent age-related bone loss.
* An abstract of this work has been presented at the ASCI National Meeting in Washington, D.C., on April 30, 1989. This work was supported in part by a research grant from the National Dairy Board (Arlington, VA) and was administered in cooperation with the National Dairy Council (Rosemont, IL).
Received June 8, 1989.
This article has been cited by other articles:
![]() |
M. R. French, F. Vernace-Inserra, and G. A. Hawker A Prospective Study to Identify Factors Affecting Adherence to Recommended Daily Calcium Intake in Women with Low Bone Mineral Density J. Am. Coll. Nutr., February 1, 2008; 27(1): 88 - 95. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Segal, L. Dvorkin, A. Lavy, G. S. Rozen, I. Yaniv, B. Raz, A. Tamir, and S. Ish-Shalom Bone Density in Axial and Appendicular Skeleton in Patients with Lactose Intolerance: Influence of Calcium Intake and Vitamin D Status J. Am. Coll. Nutr., June 1, 2003; 22(3): 201 - 207. [Abstract] [Full Text] |
||||
![]() |
J. P. Brown and R. G. Josse Lignes directrices de pratique clinique 2002 pour le diagnostic et le traitement de l'osteoporose au Canada Can. Med. Assoc. J., March 18, 2003; 168(90060): SF1 - 38. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. I. Barr Increased Dairy Product or Calcium Intake: Is Body Weight or Composition Affected in Humans? J. Nutr., January 1, 2003; 133(1): 245S - 248. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. P. Brown and R. G. Josse 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada Can. Med. Assoc. J., November 12, 2002; 167(90100): s1 - 34. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. E. Compston Sex Steroids and Bone Physiol Rev, January 1, 2001; 81(1): 419 - 447. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. L Weinsier and C. L Krumdieck Dairy foods and bone health: examination of the evidence Am. J. Clinical Nutrition, September 1, 2000; 72(3): 681 - 689. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-C. Lin, R. M. Lyle, L. D. McCabe, G. P. McCabe, C. M. Weaver, and D. Teegarden Dairy Calcium is Related to Changes in Body Composition during a Two-Year Exercise Intervention in Young Women J. Am. Coll. Nutr., June 1, 2000; 19(6): 754 - 760. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. P. Heaney Calcium, Dairy Products and Osteoporosis J. Am. Coll. Nutr., April 1, 2000; 19(90002): 83S - 99. [Abstract] [Full Text] |
||||
![]() |
D. Teegarden, R. M Lyle, W. R Proulx, C C. Johnston, and C. M Weaver Previous milk consumption is associated with greater bone density in young women Am. J. Clinical Nutrition, May 1, 1999; 69(5): 1014 - 1017. [Abstract] [Full Text] [PDF] |
||||
![]() |
S Murphy, K-T Khaw, H May, and J E Compston Milk consumption and bone mineral density in middle aged and elderly women BMJ, April 9, 1994; 308(6934): 939 - 941. [Abstract] [Full Text] |
||||
![]() |
I. R. Reid, R. W. Ames, M. C. Evans, G. D. Gamble, and S. J. Sharpe Effect of Calcium Supplementation on Bone Loss in Postmenopausal Women N. Engl. J. Med., February 18, 1993; 328(7): 460 - 464. [Abstract] [Full Text] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |