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An Enzyme Linked Immunoassay for Anti-Müllerian Hormone: A New Tool for the Evaluation of Testicular Function in Infants and Children

Unité de Recherches sur l'Endocrinologie du Développement, Unité d'Endocrinologie Pédiatrique (R.B.), INSERM, Hôpital des Enfants-Malades 75743 Paris Cedex 15, France
Unité de Recherches sur l'Endocrinologie et le Développement de l'Enfant (M.G.F.), INSERM U34, Hôpital Debrousse 69332 Lyon Cedex 5, France
Service d'Endocrinologie Pédiatrique (J.L.C.), Hôpital Saint-Vincent de Paul 75674 Paris Cedex 14, France

Address requests for reprints to: Dr. Nathalie Josso, Unité de Recherche sur l'Endocrinologie du Développement, INSERM, Ecole Normale Supérieure, 1 rue Maurice Arnoux 92120 Montrouge, France.

Anti-Müllerian hormone (AMH), also called Miillerian-inhibiting substance or factor was measured by an interspecific enzyme-linked immunoassay in the serum of 218 normal children and adults of both sexes and in 110 boys with various developmental disorders. AMH levels were high [81.67 ng/ml ± 7.44(SEM)] in normal males under 2 yr of age, fell progressively in older boys and, decreased sharply at puberty. Serum AMH was not detectable in adults or in females at any age, with very rare exceptions. AMH serum concentrations were significantly decreased in infants with disorders of sex differentiation, particularly testicular dysgenesis, and increased in patients with delayed puberty. In contrast, levels were not significantly affected by either cryptorchidism or chorionic gonadotropin stimulation. AMH shows promise as a marker of testicular function in infancy.

Received September 20, 1989.

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