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Journal of Clinical Endocrinology & Metabolism, Vol 69, 1309-1311, Copyright © 1989 by Endocrine Society

ARTICLES

Dehydroepiandrosterone sulfate levels are not suppressible by glucocorticoids before adrenarche

PM Kreitzer, SL Blethen, RS Festa and FI Chasalow
Department of Pediatrics, Schneider Children's Hospital of Long Island, Jewish Medical Center, New Hyde Park, New York 11042.

We measured dehydroepiandrosterone sulfate (DHEA-S) levels in children before and after high dose prednisone therapy. In older children (postadrenarchal), there was a 70% decrease in DHEA-S levels after 1 week. However, even after a month of therapy, DHEA-S was detectable in serum. In contrast, in younger (preadrenarchal) children, the low initial DHEA-S levels were not decreased by prednisone therapy. These findings suggest that there are two distinct regulatory pathways leading to DHEA-S, one of which is independent of ACTH.


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S. Kannisto, M. Korppi, K. Remes, and R. Voutilainen
Serum Dehydroepiandrosterone Sulfate Concentration as an Indicator of Adrenocortical Suppression in Asthmatic Children Treated with Inhaled Steroids
J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4908 - 4912.
[Abstract] [Full Text] [PDF]


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