help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Diamond, T.
Right arrow Articles by Posen, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Diamond, T.
Right arrow Articles by Posen, S.

Journal of Clinical Endocrinology & Metabolism, Vol 69, 1234-1239, Copyright © 1989 by Endocrine Society

ARTICLES

Serum vitamin D metabolites are not responsible for low turnover osteoporosis in chronic liver disease

T Diamond, D Stiel, R Mason, D Lissner, D Bikle, S Wilson and S Posen
Royal North Shore Hospital, Sydney, New South Wales, Australia.

We measured the concentrations of vitamin D-binding protein (DBP), total 25-hydroxyvitamin D, total 1,25-dihydroxyvitamin D [1,25-(OH)2D], and free 1,25-(OH)2D in sera of 107 patients with histologically proven chronic liver disease. Bone density measurements and dynamic skeletal histomorphometry were also performed. Osteoporosis, as defined by arbitrary criteria, was found in 42 patients (39%), while no patient had osteomalacia. Serum concentrations of vitamin D-binding protein, 25- hydroxyvitamin D, total 1,25-(OH)2D, and free 1,25-(OH)2D were reduced in patients with cirrhosis, but not in the noncirrhotic patients. Bone formation rates, which were low in 55 patients (51%), were correlated with liver functions, but not with the concentrations of either vitamin D metabolite. A subgroup of 44 patients with low serum 1,25-(OH)2D concentrations and low bone formation rates failed to show an appropriate increase in serum bone Gla protein after 1,25-(OH)2D3 administration even though serum concentrations of 1,25-(OH)2D rose normally. These data suggest that the bone disease in patients with hepatic disorders is not related to the serum concentrations of vitamin D metabolites or the effect of these metabolites on osteoblast function.


This article has been cited by other articles:


Home page
 J. Orthod.Home page
M. Shirazi, A. Ameri, H. Shafaroodi, P. Motahhary, T. Saleh, M. Ghasemi, and A. R. Dehpour
Orthodontic tooth movement in cholestatic and cirrhotic rats
J. Orthod., June 1, 2008; 35(2): 119 - 125.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
R. W. Norrdin, K. J. Hoopes, and D. O'Toole
Skeletal Changes in Hemochromatosis of Salers Cattle
Vet. Pathol., November 1, 2004; 41(6): 612 - 623.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J D Collier, M Ninkovic, and J E Compston
Guidelines on the management of osteoporosis associated with chronic liver disease
Gut, February 1, 2002; 50(90001): i1 - 9.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1989 by The Endocrine Society