help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holm, A. C.
Right arrow Articles by Kagedal, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holm, A. C.
Right arrow Articles by Kagedal, B.

Journal of Clinical Endocrinology & Metabolism, Vol 69, 364-368, Copyright © 1989 by Endocrine Society

ARTICLES

Kinetics of triiodothyronine uptake by erythrocytes in hyperthyroidism, hypothyroidism, and thyroid hormone resistance

AC Holm and B Kagedal
Department of Clinical Chemistry, Linkoping University, Sweden.

We studied the initial uptake of L-T3 in erythrocytes isolated from normal subjects and patients with abnormal thyroid function. The uptake was saturable, with a mean maximum velocity (Vmax) of 3.60 pmol/min.10(8) cells and a Km of 248 nmol/L in normal subjects. Women had a somewhat lower Km but a similar Vmax compared to those in men. The Vmax was increased in patients with hyperthyroidism and decreased in those with hypothyroidism. Successful treatment lowered the initially high Vmax in hyperthyroid patients and raised the low Vmax in hypothyroid patients. One subject with the rare syndrome of thyroid hormone resistance had a Vmax in the upper normal range. The mean Km values of the hyperthyroid and hypothyroid groups and of the subject with thyroid hormone resistance were similar to that of the normal subjects. The results indicate that the initial saturable uptake of T3 by the human erythrocyte is increased in hyperthyroidism and decreased in hypothyroidism.


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
G. Hennemann, R. Docter, E. C. H. Friesema, M. de Jong, E. P. Krenning, and T. J. Visser
Plasma Membrane Transport of Thyroid Hormones and Its Role in Thyroid Hormone Metabolism and Bioavailability
Endocr. Rev., August 1, 2001; 22(4): 451 - 476.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1989 by The Endocrine Society