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Journal of Clinical Endocrinology & Metabolism, Vol 69, 356-358, Copyright © 1989 by Endocrine Society

ARTICLES

Opioids stimulate growth hormone (GH) release in man independently of GH-releasing hormone

G Delitala, PA Tomasi, M Palermo, RJ Ross, A Grossman and GM Besser
Istituto di Endocrinologia e di Ematologia, Universita di Sassari, Italy.

The Met-enkephalin analog DAMME [D-Ala2,MePhe4-Met-enkephalin-(o)-o1, FK 33-824] can stimulate GH secretion in man. In this study we investigated the effects of the guanyl derivative of DAMME (G-DAMME) on the serum GH response to an analog of GHRH in normal men. GHRH-(1- 29)NH2 and G-DAMME each induced a rise in serum GH, and the increase was greater when both were given together. Since the GHRH-(1-29)NH2 dose (100 micrograms) used was a maximally stimulatory one, these results suggest that the enhancing effect of G-DAMME on GHRH-induced GH release may be mediated through inhibition of somatostatin release.


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