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Journal of Clinical Endocrinology & Metabolism Vol. 69, No. 1 215-217
doi:10.1210/jcem-69-1-215
Copyright © 1989 by the Endocrine Society.
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SPONTANEOUS, GONADOTROPIN-RELEASING HORMONE-INDUCED, AND PROGESTERONE-INHIBITED PULSATILE SECRETION OF HUMAN CHORIONIC GONADOTROPIN IN THE FIRST TRIMESTER PLACENTA IN VITRO

E.R. BARNEA and M. KAPLAN

Feto-placental Endocrinology Laboratory, The Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology and Dept. Ob/Gyn, Rambam Medical Center Haifa, Israel

Using a multichannel superfusion apparatus, the secretion of human chorionic gonadotropin (hCG) was measured at 1–6 minute intervals in placental explants at 7–9 weeks of gestation. hCG was found to be secreted in distinct pulses (4–5 fold above baseline) every 11–23 minutes peak to peak. Addition of one minute pulses of GnRH analog significantly increased, whereas pulses of progesterone decreased, pulsatile hCG secretion.

Received January 20, 1989.




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Copyright © 1989 by The Endocrine Society