This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by DANANBERG, J. Articles by GREKIN, R. J. Search for Related Content PubMed PubMed Citation Articles by DANANBERG, J. Articles by GREKIN, R. J.

Sustained Saline-Induced Secretion of Atrial Natriuretic Hormone Is not Maintained by Atrial Stretch^*

Divisions of Endocrinology, Cardiology, and Hypertension, University of Michigan Ann Arbor, Michigan 48109
The Veterans Administration Medical Center Ann Arbor, Michigan 48105

Address requests for reprints to: Jamie Dananberg, M.D., Endocrinology Section, Veterans Administration Medical Center, 2215 Fuller Road, Ann Arbor, Michigan 48105.

To determine the relationship between changes in right and left atrial pressures and changes in plasma levels of immunoreactive atrial natriuretic hormone (ANH), 11 normal men were studied during rapid infusion of 1 L 150 mmol/L NaCl. Right atrial pressure, pulmonary capillary wedge pressure, and peripheral plasma ANH levels were measured serially for 30 min in 6 men and for 90 min in 5 men. There were significant increases in right atrial pressure at 15 and 30 min [4.8 ± 0.4 (±SE) vs. 8.9 ± 0.3 and 6.5 ± 0.4 mm Hg; P < 0.001] and in pulmonary capillary wedge pressure at the same time intervals [8.5 ± 0.6 vs. 13.6 ± 0.8 (P < 0.001) and 10.6 ± 0.6 mm Hg (P < 0.01)]. Plasma ANH increased significantly at 30 min (11.5 ± 2.4 vs. 20.6 ± 3.0 pmol/L; P < 0.001). Regression analysis revealed no correlation between the increase in plasma ANH at 30 min and the increase in either right atrial or pulmonary capillary wedge pressure at 15 min (r = 0.46; P = 0.16 for right atrial pressure; r = 0.02; P = 0.96 for pulmonary capillary wedge pressure). In the 5 men studied for 90 min, right atrial and pulmonary capillary wedge pressures returned to basal values by 45 min. In contrast, plasma ANH levels remained significantly elevated at all sampling times from 30–90 min (P < 0.001); the peak value occurred at 75 min. We conclude that ANH secretion persists after saline infusion and that the cause of this prolonged secretion is not atrial stretch.

^* This work was supported in part by Grant HL-18575 from the NHLBI, Grant 5MO1-RR-42 from the Division of Research Resources, NIH, and grants from the American Heart Association and the Research Service of the V.A.

Received August 19, 1988.

This article has been cited by other articles:

				H. Kawakami, T. Sumimoto, H. Matsuoka, T. Kobayashi, T. Ohtani, M. Abe, Y. Shigematsu, M. Hamada, and K. Hiwada Atrial Natriuretic Peptide and Left Atrial Systolic Function in Normal Subjects Angiology, November 1, 1993; 44(11): 903 - 907. [Abstract] [PDF]