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Journal of Clinical Endocrinology & Metabolism, Vol 68, 535-541, Copyright © 1989 by Endocrine Society
ARTICLES |
AC Faria, JD Veldhuis, MO Thorner and ML Vance
Department of Internal Medicine, University of Virginia Medical School, Charlottesville 22908.
The half-life (t1/2) of disappearance of endogenous GH from serum was studied using physiological effectors to stimulate and then suppress GH release. GH secretion was stimulated by a single iv injection of GHRH, followed 45 min later by an iv bolus dose and then a 2.5-h infusion of somatostatin (SRIH) to suppress further release. The in vivo t1/2 of GH in seven men was calculated from serum GH concentrations measured at frequent intervals after beginning the SRIH infusion. The mean t1/2 of endogenous GH was 18.9 +/- 0.8 (+/- SE) min by monoexponential analysis and 3.5 +/- 0.7 and 20.7 +/- 0.7 min by biexponential fitting. In these normal men, the decline in GH concentrations after GHRH and SRIH administration was similar to that after the administration of GHRH alone, which yielded a t1/2 of 20.3 +/- 1.9 min. We conclude that the physiological kinetics of endogenous GH removal/disappearance can be estimated in vivo in man using GHRH with or without SRIH infusion.
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A. Iranmanesh, C. Y. Bowers, and J. D. Veldhuis Activation of Somatostatin-Receptor Subtype-2/-5 Suppresses the Mass, Frequency, and Irregularity of Growth Hormone (GH)-Releasing Peptide-2-Stimulated GH Secretion in Men J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4581 - 4587. [Abstract] [Full Text] [PDF]
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J. G. Langendonk, A. E. Meinders, J. Burggraaf, M. Frolich, C. A. M. Roelen, R. C. Schoemaker, A. F. Cohen, and H. Pijl Influence of obesity and body fat distribution on growth hormone kinetics in humans Am J Physiol Endocrinol Metab, November 1, 1999; 277(5): E824 - E829. [Abstract] [Full Text] [PDF]
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G. M. Bright, J. D. Veldhuis, A. Iranmanesh, G. Baumann, H. Maheshwari, and J. Lima Appraisal of Growth Hormone (GH) Secretion: Evaluation of a Composite Pharmacokinetic Model That Discriminates Multiple Components of GH Input J. Clin. Endocrinol. Metab., September 1, 1999; 84(9): 3301 - 3308. [Abstract] [Full Text]
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N. Shah, J. Aloi, W. S. Evans, and J. D. Veldhuis Time Mode of Growth Hormone (GH) Entry into the Bloodstream and Steady-State Plasma GH Concentrations, Rather Than Sex, Estradiol, or Menstrual Cycle Stage, Primarily Determine the GH Elimination Rate in Healthy Young Women and Men J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2862 - 2869. [Abstract] [Full Text]
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