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Marked Elevation and Cyclic Variation of Corticosteroid-Binding Globulin: An Inherited Abnormality?^*

Department of Endocrinology and Isotopes, Salvatorziekenhuis (J.L.C.) 3500 Hasselt, Belgium
the Laboratory for Experimental Medicine and Endocrinology, Onderwijs en Nauorsing, Gasthuisberg (W.H.) B-3000 Leuven, Belgium

Address all correspondence and requests for reprints to: Dr. W. Heyns, Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Onderwijs en Navorsing, Gasthuisberg, B-3000 Leuven, Belgium.

Unexplained high serum corticosteroid-binding globulin (CBG) concentrations [mean values, 78.8 and 55.7 mg/L; normal women, 38.8 ± 3.8 (±SD) mg/L] were found repeatedly in two apparently healthy sisters who were not pregnant or taking exogenous estrogens. One had substantial variations in serum CBG and sex hormone-binding globulin concentrations during the menstrual cycle, which paralleled the normal cyclic changes in serum estradiol. The other woman was postmenopausal and had a high serum CBG concentration despite of low serum estradiol levels. We conclude those women have an inherited abnormality in CBG production.

^* This work was supported in part by NFWO Grant 3.0015.88.

Received May 31, 1988.