This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via Google Scholar Google Scholar Articles by OHARA, A. Articles by MORI, T. Search for Related Content PubMed PubMed Citation Articles by OHARA, A. Articles by MORI, T.

Stimulatory Effects of Purified Human Follicle-Stimulating Hormone on Estradiol Production in the Human Luteal Phase^*

AKIRA OHARA, SHUNZO TAII and TAKAHIDE MORI

Department of Gynecology and Obstetrics, Kyoto University Faculty of Medicine Sakyo-ku, Kyoto 606, Japan

A bolus iv injection of 150 IU purified human urinary FSH (hFSH) or saline was given to 21 normal women during 3 different luteal phases (early luteal phase, n = 7; midluteal, n = 8; late luteal, n = 6), and the responses of ovarian steroids and gonadotropins were analyzed sequentially for 24 h after hFSH injection. A rapid and dramatic increase in serum FSH concentrations occurred after each hFSH injection, followed by a gradual decrease. Serum LH concentrations, including hourly fluctuations, were significantly higher after FSH administration than after NaCl injection at the same time during the preceding cycle. Neither serum progesterone nor testosterone levels were affected by the hFSH injection in any of the 3 luteal phases, but in the early and midluteal phases serum estradiol levels were higher than the preinjection values and those during the control cycles.

These results indicate that FSH stimulates aromatization of luteal tissue in vivo as it does in vitro. Thus, FSH in addition to LH as the indispensable luteotropin may have a permissive role in the regulation of corpus luteum function.

^* This work was supported in part by Grant-in-Aids 61480350 and 61570790 from the Ministry of Education, Japan.

To whom requests for reprints should be addressed.

Received November 16, 1987.