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Journal of Clinical Endocrinology & Metabolism Vol. 68, No. 2 317-321
doi:10.1210/jcem-68-2-317
Copyright © 1989 by the Endocrine Society.
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Changes in the Hypothalamic-Pituitary-Gonadal Axis in Human Immunodeficiency Virus-Infected Homosexual Men*

THOMAS S. CROXSON, WILLIAM E. CHAPMAN, LORRAINE K. MILLER, CHARLES D. LEVIT, RUBY SENIE and BARNETT ZUMOFF

Departments of Medicine and Pathology, Beth Israel Medical Center New York, New York 10003

Address all correspondence and requests for reprints to: Dr. Thomas S. Croxson, Department of Medicine, Beth Israel Medical Center, First Avenue at 16th Street, New York, New York 10003.

Serum total testosterone, total 17β-estradiol, LH, FSH, and PRL concentrations were measured by RIA in 59 homosexual men infected with the human immunodeficiency virus (32 clinically healthy antibody-positive men (HH+), 20 men with acquired immune deficiency syndrome (AIDS), and 7 men with AIDS-related complex (ARC). The results were compared with those of 26 antibody-negative homosexual men (HH–) who served as controls. The mean serum total testosterone concentration was significantly lower in the men with AIDS [414 ± 230 (±SD) ng/dL (14.5 ± 8.0)] than in the HH– men [550 ± 172 ng/dL (19.0 ± 6.0 nmol/L); P < 0.05]. The mean serum LH level was significantly higher in the men with AIDS (26 ± 14 vs. 14 ± 4 IU/L in HH- men; P < 0.01) and slightly but significantly higher in the men with ARC (19 ± 8 IU/L; 0.10 < P > 0.05). Serum FSH also was significantly higher in the men with AIDS (P < 0.05). Serum PRL was significantly higher in the men with ARC (10 ± 2 µg/L; P < 0.05) and AIDS (16 ± 10 µg/L; P < 0.001) than in the HH- men (8 ± 3 µg/L). Serum sex hormone-binding globulin levels were similar in HH– men and men with AIDS as were serum T responses to hCG administration for 2 days. These results suggest that alterations of the hypothalamic-pituitary-gonadal axis indicative of primary hypogonadism accompany human immunodeficiency virus infection in homosexual men.

* Presented in part at the Second International Congress on AIDS, June 21-28,1986, Paris, France. This work was supported by the AIDS Research Fund, Beth Israel Medical Center.

Received February 19, 1988.




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