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Journal of Clinical Endocrinology & Metabolism Vol. 68, No. 1 232-234
doi:10.1210/jcem-68-1-232
Copyright © 1989 by the Endocrine Society.
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FUNCTIONAL HYPERSOMATOTROPISM IN SMALL FOR GESTATIONAL AGE (SGA) NEWBORN INFANTS

M. DEIBER*, P. CHATELAIN**, D. NAVILLE**, G. PUTET* and B. SALLE

* DEPARTMENT OF NEONATOLOGY - HOPITAL EDOUARD HERRIOT 69437 LYON CEDEX 03 - FRANCE
** INSERM U 307 - HOPITAL DEBROUSSE 29 RUE SOEUR BOUVIER 69005 LYON - FRANCE

Basal plasma GH levels and the GH responses to an injection of 1 µg/kg 1–44(NH2) GHRH were determined on day 3 postnatally in 5 small gestational age (SGA) twin newborns and their appropriate gestational age (AGA) co-twins, and in 10 SGA singleton newborns and 6 AGA singleton newborns. The mean basal plasma GH level was higher in the SGA than in the AGA infants but the difference was significant only for singleton newborns (p < 0.01). The mean peak plasma GH level was markedly increased in SGA compared to AGA infants (p < 0.05 for twins, p < 0.01 for singletons). Twelve SGA infants re-tested at 1 month had lower basal and peak plasma GH levels (p < 0.001 and p < 0.01). In 21 SGA and 17 AGA infants, serum IGF-I, measured by RIA between 12 and 96 hours after birth, was significantly higher in SGA than in AGA (p < 0.001). These results suggest that, whatever the mechanism, functional hypersomatotropism is present at day 3 in SGA infants. This hypersomatotropism may participate in the early catch-up growth process.

Received June 9, 1988.




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