Renin, Prorenin, and Immunoreactive Renin in Vitreous Fluid From Eyes With and Without Diabetic Retinopathy
A. H. J. DANSER,
M. A. VAN DEN DORPEL,
J. DEINUM,
F. H. M. DERKX,
A. A. M. FRANKEN,
E. PEPERKAMP,
P. T. V. M. DE JONG and
M. A. D. H. SCHALEKAMP
Departments of Internal Medicine I and Ophthalmology, Erasmus University Rotterdam, The Netherlands
Address all correspondence and requests for reprints to: Dr. M. A. D. H. Schalekamp, M.D., Department of Internal Medicine I, Room H 360, University Hospital Dijkzigt, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Renin, prorenin, and immunoreactive renin were present in vitreousand subretinal fluid of eyes from subjects with and withoutdiabetic retinopathy. Renin substrate, albumin, transferrin,and immunoglobin G were also found in these ocular fluids. Inmany samples renin levels were close to the detection limitof the assay. The levels of renin substrate, albumin, transferrin,and immunoglobulin G varied widely among ocular fluid samples,but in each individual sample the levels were, relative to eachother, similar to those in plasma. In contrast, the proreninlevel in ocular fluid was up to 100 times higher than expectedon the basis of the plasma protein content of ocular fluid.Moreover, there was little difference in proreninconcentrationsbetween samples with low and high plasma protein contents. Prorenin,relative to albumin and other plasma proteins, was higher invitreous fluid from eyes with proliferative diabetic retinopathycomplicated by traction retinal detachment than in eyes of nondiabeticsubjects with spontaneous retinal detachment. It appears thatprorenin (and possibly renin) in ocular fluid is controlledby an active and specific process, possibly local synthesiswithin the eye. In view of the vascular actions of angiotensinII, an intraocular renin-angiotensin system may play a rolein diabetic retinopathy.
Received May 18, 1988.
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