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Prolonged Exercise Increases Serum Insulin-Like Growth Factor-Binding Protein Concentrations^*

First Department of Obstetrics and Gynecology (A.-M.S., M.S.), Third Department of Medicine (T.S.), Second Department of Medicine (H. Y.-J., V.A.K.) Helsinki, Finland
The Department of Clinical Chemistry (S.-L.K.), Helsinki University Central Hospital Helsinki, Finland

Address all correspondence and requests for reprints to: Dr. Anne- Maria Suikkari, Department I of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, SF-00290 Helsinki, Finland.

We studied the response of serum 34K insulinlike growth factor-binding protein (IGF-BP) to two types of prolonged exercise. In the first study, 11 normal men performed cycle ergometer exercise, after an overnight fast, for 3 h at the intensity corresponding to 45–50% of their maximal aerobic power. After the exercise, the mean serum IGF-BP concentration was 4.9-fold higher than the baseline level (P < 0.01), while the IGF-I concentration did not change. Resting for the same time period resulted in a 38% fall in the serum IGF-BP level (P < 0.01). In the second study, 10 normal men and 8 type 1 diabetic men exercised, on the average, for 7.5 h in a 75-km cross-country ski race. The mean serum IGF-BP concentration increased 5.4- fold (P < 0.01) in the normal men and 4.2-fold (P < 0.01) in thediabetic men. The serum IGF-I concentration decreased by 19% and 21% in the normal and diabetic men, respectively (P < 0.01). After completion of the ski race, the serum insulin and IGF-BP levels (r = –0.70; P < 0.05), and serum IGF-I and IGFBP levels (r = –0.72; P < 0.05) were inversely correlated in the normal men. No such correlations were found in the diabetic men. We conclude that 1) long term exercise increases serum IGF-BP concentrations in both normal and type 1diabetic men; and 2) the increases are inversely related to alterations in serum IGF-I and insulin concentrations in normal men. These data suggest that IGF-BP may be involved in regulation of the biological action of IGF-I during prolonged exercise.

^* This work was supported by grants from the Cancer Society of Finland, the Foundation of Medical Research Duodecim, the Finnish Ministry of Education,the Academy of Finland, and Else and Wilhelm Stockman's Foundation.

Received April 4, 1988.

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