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Journal of Clinical Endocrinology & Metabolism Vol. 67, No. 6 1322-1324
doi:10.1210/jcem-67-6-1322
Copyright © 1988 by the Endocrine Society.
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CHORIONIC GONADOTROPIN SECRETION BY HUMAN EMBRYOS IN VITRO

D LACHLAN HAY1 and A LOPATA2

1 Department of Pathology, The Royal Women’s Hospital, and Reproductive Biology Unit Melbourne, Australia, 3053
2 Department of Obstetrics and Gynaecology, University of Melbourne Melbourne, Australia, 3053

Embryos (n = 38) from an in vitro fertilization (IVF) program, unsuitable for transfer or cryopreservation, were maintained in culture for 14 days. The time course of hCG secretion into culture fluid was compared to observed embryo development. The earliest significant hCG rise was detected at day 7 post insemination for a partially hatched blastocyst, with hCG levels increasing 50-fold following blastocyst attachment to the surface of the culture vessel. Secretion of hCG was amplified by the addition of serum. There was no significant free {alpha}chCG or βhCG secretion between days 6 – 12. We conclude that hCG production depends on the pathway of cytotrophoblast differentiation and commences with the appearance of the Gl phase in embryonic cells at the late blastocyst stage.

Received July 4, 1988.




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Copyright © 1988 by The Endocrine Society