| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 67, 1134-1139, Copyright © 1988 by Endocrine Society
ARTICLES |
AM Richards, D McDonald, MA Fitzpatrick, MG Nicholls, EA Espiner, H Ikram, S Jans, S Grant and T Yandle
Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand.
Whether atrial natriuretic hormone (ANH) has biological effects at physiological plasma levels in man is not known. Accordingly, we investigated the effects of a 3-h low dose infusion of human ANF (0.75 pmol/kg.min; i.e. 0.0023 micrograms/kg.min) in six normal men, whose sodium intake was normal while sitting, in a single blind, random order, placebo-controlled study. The ANF infusions induced changes in plasma ANH concentrations entirely within the range for normal subjects. The small increases in plasma ANH values were associated with a significant rise in urinary excretion of sodium, magnesium, calcium, and cGMP. PRA and plasma aldosterone concentrations uniformly decreased to 50% and 64% of placebo values, respectively. Systolic and mean arterial pressures fell significantly from preinfusion values during the ANH infusions. These findings constitute strong evidence that ANH is a hormone of physiological significance in the regulation of body fluid volumes in normal man.
This article has been cited by other articles:
![]() |
R J Hillock, C M Frampton, T G Yandle, R W Troughton, J G Lainchbury, and A M Richards B-type natriuretic peptide infusions in acute myocardial infarction Heart, May 1, 2008; 94(5): 617 - 622. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. R. Potter, S. Abbey-Hosch, and D. M. Dickey Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions Endocr. Rev., February 1, 2006; 27(1): 47 - 72. [Abstract] [Full Text] [PDF] |
||||
![]() |
A.M. Makikallio, T.H. Makikallio, J.T. Korpelainen, O. Vuolteenaho, J.M. Tapanainen, K. Ylitalo, K.A. Sotaniemi, H.V. Huikuri, and V.V. Myllyla Natriuretic Peptides and Mortality After Stroke Stroke, May 1, 2005; 36(5): 1016 - 1020. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Schmitt, A. Qasem, C. McEniery, I. B. Wilkinson, V. Tatarinoff, K. Noble, J. Klemes, N. Payne, M. P. Frenneaux, J. Cockcroft, et al. Role of natriuretic peptides in regulation of conduit artery distensibility Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1167 - H1171. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. E. Davis, C. J. Pemberton, T. G. Yandle, J. G. Lainchbury, M. T. Rademaker, M. G. Nicholls, C. M. Frampton, and A. M. Richards Urocortin-1 Infusion in Normal Humans J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1402 - 1409. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. G. MELO, M. E. STEINHELPER, S. C. PANG, Y. TSE, and U. ACKERMANN ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models Physiol Genomics, June 29, 2000; 3(1): 45 - 58. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.-i. Ando, M. A. Rahman, G. C. Butler, B. L. Senn, and J. S. Floras Comparison of Candoxatril and Atrial Natriuretic Factor in Healthy Men : Effects on Hemodynamics, Sympathetic Activity, Heart Rate Variability, and Endothelin Hypertension, December 1, 1995; 26(6): 1160 - 1166. [Abstract] [Full Text] |
||||
![]() |
S. Shigematsu, T. Yamada, T. Aizawa, N. Takasu, and Z. Shimizu Differential Effects of Nifedipine on Plasma Atrial Natriuretic Peptide in Normal Subjects and Hypertensive Patients Angiology, January 1, 1992; 43(1): 40 - 46. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |