| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
,
DAVID McDONALD,
MICHAEL ANDREW FITZPATRICK,
MICHAEL GARY NICHOLLS,
ERIC ARNOLD ESPINER,
HAMID IKRAM,
SIEGFRIED JANS,
SUSAN GRANT and
TIMOTHY YANDLE
Departments of Endocrinology and Cardiology, Princess Margaret Hospital Christchurch 2, New Zealand
Address all correspondence and requests for reprints to: Dr. A. Mark Richards, Department of Medicine, Princess Margaret Hospital, Christchurch 2, New Zealand.
Whether atrial natriuretic hormone (ANH) has biological effects at physiological plasma levels in man is not known. Accordingly, we investigated the effects of a 3-h low doseinfusion of human ANF (0.75 pmol/kg·min; i.e. 0.0023 µg/kg·min) in six normal men, whose sodium intake was normal while sitting, in a single blind, random order, placebo-controlled study. The ANF infusions induced changes in plasma ANH concentrations entirely within the range for normal subjects. The small increases in plasma ANH values were associated with a significant significant rise in urinary excretion of sodium, magnesium, calcium, and cGMP. PRA and plasma aldosterone concentrations uniformly decreased to 50% and 64% of placebo values, respectively. Systolic and mean arterial pressures fell significantly from preinfusion values during the ANH infusions.
These findings constitute strong evidence that ANH is a hormone of physiological significance in the regulation of body fluid volumes in normal man.
* This work was supported by the New Zealand National Heart Foundation and the Medical Research Council of New Zealand.
New Zealand Medical Research Council-Wellcome Research Fellow.
Received April 19, 1988.
This article has been cited by other articles:
![]() |
S Kurl, M Ala-Kopsala, H Ruskoaho, T Makikallio, K Nyyssonen, O Vuolteenaho, J Sivenius, J T Salonen, and J A Laukkanen Plasma N-terminal fragments of natriuretic peptides predict the risk of stroke and atrial fibrillation in men Heart, July 1, 2009; 95(13): 1067 - 1071. [Abstract] [Full Text] [PDF] |
||||
![]() |
R J Hillock, C M Frampton, T G Yandle, R W Troughton, J G Lainchbury, and A M Richards B-type natriuretic peptide infusions in acute myocardial infarction Heart, May 1, 2008; 94(5): 617 - 622. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. R. Potter, S. Abbey-Hosch, and D. M. Dickey Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions Endocr. Rev., February 1, 2006; 27(1): 47 - 72. [Abstract] [Full Text] [PDF] |
||||
![]() |
A.M. Makikallio, T.H. Makikallio, J.T. Korpelainen, O. Vuolteenaho, J.M. Tapanainen, K. Ylitalo, K.A. Sotaniemi, H.V. Huikuri, and V.V. Myllyla Natriuretic Peptides and Mortality After Stroke Stroke, May 1, 2005; 36(5): 1016 - 1020. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Schmitt, A. Qasem, C. McEniery, I. B. Wilkinson, V. Tatarinoff, K. Noble, J. Klemes, N. Payne, M. P. Frenneaux, J. Cockcroft, et al. Role of natriuretic peptides in regulation of conduit artery distensibility Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1167 - H1171. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Vanderheyden, J. Bartunek, and M. Goethals Brain and other natriuretic peptides: molecular aspects Eur J Heart Fail, March 15, 2004; 6(3): 261 - 268. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. E. Davis, C. J. Pemberton, T. G. Yandle, J. G. Lainchbury, M. T. Rademaker, M. G. Nicholls, C. M. Frampton, and A. M. Richards Urocortin-1 Infusion in Normal Humans J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1402 - 1409. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. G. MELO, M. E. STEINHELPER, S. C. PANG, Y. TSE, and U. ACKERMANN ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models Physiol Genomics, June 29, 2000; 3(1): 45 - 58. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.-i. Ando, M. A. Rahman, G. C. Butler, B. L. Senn, and J. S. Floras Comparison of Candoxatril and Atrial Natriuretic Factor in Healthy Men : Effects on Hemodynamics, Sympathetic Activity, Heart Rate Variability, and Endothelin Hypertension, December 1, 1995; 26(6): 1160 - 1166. [Abstract] [Full Text] |
||||
![]() |
S. Shigematsu, T. Yamada, T. Aizawa, N. Takasu, and Z. Shimizu Differential Effects of Nifedipine on Plasma Atrial Natriuretic Peptide in Normal Subjects and Hypertensive Patients Angiology, January 1, 1992; 43(1): 40 - 46. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |