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Atrial Natriuretic Hormone Has Biological Effects in Man at Physiological Plasma Concentrations^*

ARTHUR MARK RICHARDS, DAVID McDONALD, MICHAEL ANDREW FITZPATRICK, MICHAEL GARY NICHOLLS, ERIC ARNOLD ESPINER, HAMID IKRAM, SIEGFRIED JANS, SUSAN GRANT and TIMOTHY YANDLE

Departments of Endocrinology and Cardiology, Princess Margaret Hospital Christchurch 2, New Zealand

Address all correspondence and requests for reprints to: Dr. A. Mark Richards, Department of Medicine, Princess Margaret Hospital, Christchurch 2, New Zealand.

Whether atrial natriuretic hormone (ANH) has biological effects at physiological plasma levels in man is not known. Accordingly, we investigated the effects of a 3-h low doseinfusion of human ANF (0.75 pmol/kg·min; i.e. 0.0023 µg/kg·min) in six normal men, whose sodium intake was normal while sitting, in a single blind, random order, placebo-controlled study. The ANF infusions induced changes in plasma ANH concentrations entirely within the range for normal subjects. The small increases in plasma ANH values were associated with a significant significant rise in urinary excretion of sodium, magnesium, calcium, and cGMP. PRA and plasma aldosterone concentrations uniformly decreased to 50% and 64% of placebo values, respectively. Systolic and mean arterial pressures fell significantly from preinfusion values during the ANH infusions.

These findings constitute strong evidence that ANH is a hormone of physiological significance in the regulation of body fluid volumes in normal man.

^* This work was supported by the New Zealand National Heart Foundation and the Medical Research Council of New Zealand.

New Zealand Medical Research Council-Wellcome Research Fellow.

Received April 19, 1988.

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