help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lookingbill, D. P.
Right arrow Articles by Demers, L. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lookingbill, D. P.
Right arrow Articles by Demers, L. M.

Journal of Clinical Endocrinology & Metabolism, Vol 67, 986-991, Copyright © 1988 by Endocrine Society


ARTICLES

Correlation of serum 3 alpha-androstanediol glucuronide with acne and chest hair density in men

DP Lookingbill, N Egan, RJ Santen and LM Demers
Division of Dermatology, Pennsylvania State University College of Medicine, Hershey 17033.

Serum 3 alpha-androstanediol glucuronide (3 alpha-Adiol-G) is considered to be an indicator of peripheral tissue androgen metabolism. Precursor circulating androgens are converted in peripheral tissue to dihydrotestosterone (DHT), which is ultimately metabolized to 3 alpha- Adiol-G and secreted from the cell. Elevated serum 3 alpha-Adiol-G concentrations have been reported in women in hyperandrogenic states. We studied 44 consecutive male medical students for chest hair density, acne, and serum dehydroepiandrosterone sulfate (DHEA-S), total testosterone (total T), free and albumin-bound (bioavailable) T (bio T), and 3 alpha-Adiol-G concentrations. Although there was considerable overlap of serum 3 alpha-Adiol-G values among the groups defined by hair density or acne scores, we found statistically significant correlations between serum 3 alpha-Adiol-G and chest hairiness (P = 0.0034), acne (P = 0.0005), and a combined chest hairiness and acne score (P = 0.0018). There was no significant correlation between these clinical parameters and the levels of precursor androgens. There was, however, a strong correlation between serum 3 alpha-Adiol-G and bio T (P = 0.0005), suggesting that in men serum 3 alpha-Adiol-G levels may be dependent upon available free and albumin-bound T. The correlations in men of serum 3 alpha-Adiol-G with chest hair density, acne, and the hairiness and acne index supports the hypothesis that the serum levels of 3 alpha-Adiol-G reflect the extent of androgen action in peripheral tissues.


This article has been cited by other articles:


Home page
J. Clin. Endocrinol. Metab.Home page
E. Carmina, S. Bucchieri, A. Esposito, A. Del Puente, P. Mansueto, F. Orio, G. Di Fede, and G. Rini
Abdominal Fat Quantity and Distribution in Women with Polycystic Ovary Syndrome and Extent of Its Relation to Insulin Resistance
J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2500 - 2505.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
E. Carmina, F. Rosato, A. Janni, M. Rizzo, and R. A. Longo
Relative Prevalence of Different Androgen Excess Disorders in 950 Women Referred because of Clinical Hyperandrogenism
J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 2 - 6.
[Abstract] [Full Text] [PDF]


Home page
Hum ReprodHome page
L. Falsetti, A. Gambera, and G. Tisi
Efficacy of the combination ethinyl oestradiol and cyproterone acetate on endocrine, clinical and ultrasonographic profile in polycystic ovarian syndrome
Hum. Reprod., January 1, 2001; 16(1): 36 - 42.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
E. J. Giltay and L. J. G. Gooren
Effects of Sex Steroid Deprivation/Administration on Hair Growth and Skin Sebum Production in Transsexual Males and Females
J. Clin. Endocrinol. Metab., August 1, 2000; 85(8): 2913 - 2921.
[Abstract] [Full Text]


Home page
J. Clin. Endocrinol. Metab.Home page
B. Jin, L. Turner, Z. Zhou, E. L. Zhou, and D. J. Handelsman
Ethnicity and Migration as Determinants of Human Prostate Size
J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3613 - 3619.
[Abstract] [Full Text] [PDF]


Home page
Arch DermatolHome page
G. F. Webster
Acne Vulgaris: State of the Science
Arch Dermatol, September 1, 1999; 135(9): 1101 - 1102.
[Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
S. J. Santner, B. Albertson, G.-y. Zhang, G.-h. Zhang, M. Santulli, C. Wang, L. M. Demers, C. Shackleton, and R. J. Santen
Comparative Rates of Androgen Production and Metabolism in Caucasian and Chinese Subjects
J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 2104 - 2109.
[Abstract] [Full Text]


Home page
J. Clin. Endocrinol. Metab.Home page
J. I. Schwartz, W. K. Tanaka, D. Z. Wang, D. L. Ebel, L. A. Geissler, A. Dallob, B. Hafkin, and B. J. Gertz
MK-386, an Inhibitor of 5{alpha}-Reductase Type 1, Reduces Dihydrotestosterone Concentrations in Serum and Sebum without Affecting Dihydrotestosterone Concentrations in Semen
J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1373 - 1377.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
M. Beaulieu, E. Levesque, D. W. Hum, and A. Belanger
Isolation and Characterization of a Novel cDNA Encoding a Human UDP-Glucuronosyltransferase Active on C19 Steroids
J. Biol. Chem., September 13, 1996; 271(37): 22855 - 22862.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1988 by The Endocrine Society