help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, Y. D.
Right arrow Articles by Reaven, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, Y. D.
Right arrow Articles by Reaven, G. M.

Journal of Clinical Endocrinology & Metabolism, Vol 67, 1084-1088, Copyright © 1988 by Endocrine Society

ARTICLES

Effect of time on measurement of hepatic glucose production

YD Chen, AL Swislocki, CY Jeng, JH Juang and GM Reaven
Department of Medicine, Stanford University School of Medicine, California.

Basal hepatic glucose production (HGP) was determined in obese and nonobese normal subjects and patients with noninsulin-dependent diabetes mellitus (NIDDM) using [3-3H]glucose and the nonsteady state equations of Steele. When HGP was estimated at hourly intervals from 0800-1300 h, it became evident that calculated values for HGP fell for the first 2-4 h until a plateau was reached, and this decline was quite precipitous during the first 2 h in patients with NIDDM. Furthermore, when the same patient with NIDDM was studied on two occasions, similar values for HGP were not uniformly obtained unless measurements were made at least 4 h after [3-3H] glucose administration. Since it has been the convention to use the nonsteady state equations of Steele to calculate HGP in patients with NIDDM 2 h after [3-3H] glucose administration, it is almost certain that published values for HGP in patients with NIDDM are falsely high. Based upon the data presented, we suggest that HGP using [3-3H]glucose and the nonsteady state Steele equations be measured for at least a 4-h period in patients with NIDDM in order to increase the validity of the calculated value.


This article has been cited by other articles:


Home page
 DiabetesHome page
S. K. Tigas, A. L. Sunehag, and M. W. Haymond
Impact of Duration of Infusion and Choice of Isotope Label on Isotope Recycling in Glucose Homeostasis
Diabetes, November 1, 2002; 51(11): 3170 - 3175.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Radziuk
Insulin Sensitivity and Its Measurement: Structural Commonalities among the Methods
J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4426 - 4433.
[Abstract] [Full Text]

Home page
 NEJMHome page
S. E. Inzucchi, D. G. Maggs, G. R. Spollett, S. L. Page, F. S. Rife, V. Walton, and G. I. Shulman
Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus
N. Engl. J. Med., March 26, 1998; 338(13): 867 - 873.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. K. Wi, J. K. Kim, and J. H. Youn
Reduced glucose clearance as the major determinant of postabsorptive hyperglycemia in diabetic rats
Am J Physiol Endocrinol Metab, February 1, 1998; 274(2): E257 - E264.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1988 by The Endocrine Society