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Insulin Absorption and Subcutaneous Blood Flow in Normal Subjects During Insulin-Induced Hypoglycemia^*

Departments of Medicine (E.F.-F, R.G.) and Clinical Physiology (B.L.), Huddinge Hospital Stockholm, Sweden

Address all correspondence and requests for reprints to: Dr. Eva Fernqvist-Forbes, Department of Medicine, Huddinge Hospital, S-14186 Huddinge, Sweden.

We studied the effects of insulin-induced hypoglycemia on the absorption of 10 U ¹²⁵I-labeled soluble human insulin injected sc in the thigh in 10 normal subjects. The disappearance of ¹²⁵I from the injection site was followed by external -counting. Subcutaneous blood flow (ATBF) was measured concomitantly with the ¹³³Xe washout technique. The plasma glucose nadir [mean, 2.0 ± 0.1 (±SE) mmol/L] occurred at 33 ± 3 min and resulted in maximal arterial plasma epinephrine concentrations of approximately 6 nmol/L. From 30 min before to 60 min after the glucose nadir the [¹²⁵I]insulin absorption rate was depressed compared to that during normoglycemia. The first order disappearance rate constants were reduced by approximately 50% (P < 0.01) during the first 30-min interval after the glucose nadir. During the same period ATBF increased by 100% (P < 0.05). The results suggest that in normal subjects the absorption of soluble insulin from a sc depot is depressed in connection with hypoglycemia, despite considerably elevated ATBF.

^* Presented in part at the 22nd Annual Meeting of the European Association for the Study of Diabetes, Rome, Italy, September 1986. This work was supported by the Swedish Medical Research Council (Project 7154), Novo Industri A/S, the Swedish Diabetes Association, the Karolinska Institute, and the Hagberg Foundation.

Received November 10, 1987.

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