help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fernqvist-Forbes, E.
Right arrow Articles by Gunnarsson, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fernqvist-Forbes, E.
Right arrow Articles by Gunnarsson, R.

Journal of Clinical Endocrinology & Metabolism, Vol 67, 619-623, Copyright © 1988 by Endocrine Society

ARTICLES

Insulin absorption and subcutaneous blood flow in normal subjects during insulin-induced hypoglycemia

E Fernqvist-Forbes, B Linde and R Gunnarsson
Department of Medicine, Huddinge Hospital, Stockholm, Sweden.

We studied the effects of insulin-induced hypoglycemia on the absorption of 10 U 125I-labeled soluble human insulin injected sc in the thigh in 10 normal subjects. The disappearance of 125I from the injection site was followed by external gamma-counting. Subcutaneous blood flow (ATBF) was measured concomitantly with the 133Xe washout technique. The plasma glucose nadir [mean, 2.0 +/- 0.1 (+/- SE) mmol/L] occurred at 33 +/- 3 min and resulted in maximal arterial plasma epinephrine concentrations of approximately 6 nmol/L. From 30 min before to 60 min after the glucose nadir the [125I]insulin absorption rate was depressed compared to that during normoglycemia. The first order disappearance rate constants were reduced by approximately 50% (P less than 0.01) during the first 30-min interval after the glucose nadir. During the same period ATBF increased by 100% (P less than 0.05). The results suggest that in normal subjects the absorption of soluble insulin from a sc depot is depressed in connection with hypoglycemia, despite considerably elevated ATBF.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
S. Enoksson, S. K. Caprio, F. Rife, G. I. Shulman, W. V. Tamborlane, and R. S. Sherwin
Defective Activation of Skeletal Muscle and Adipose Tissue Lipolysis in Type 1 Diabetes Mellitus during Hypoglycemia
J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1503 - 1511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Aussedat, M. Dupire-Angel, R. Gifford, J. C. Klein, G. S. Wilson, and G. Reach
Interstitial glucose concentration and glycemia: implications for continuous subcutaneous glucose monitoring
Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E716 - E728.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
A. Kamel, S. Norgren, B. Persson, and C. Marcus
Insulin induced hypoglycaemia: comparison of glucose and glycerol concentrations in plasma and microdialysate from subcutaneous adipose tissue
Arch. Dis. Child., January 1, 1999; 80(1): 42 - 45.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1988 by The Endocrine Society