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Journal of Clinical Endocrinology & Metabolism Vol. 67, No. 2 404-406
doi:10.1210/jcem-67-2-404
Copyright © 1988 by the Endocrine Society.
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Circadian Rhythm of Adrenergic Regulation of Adrenocorticotropin and Cortisol Secretion in Man

MAGDALENA RACZKOWSKA NAYLOR, K. RANGA RAMA KRISHNAN, ANANTH N. MANEPALLI, JAMES C. RITCHIE, JR., WILLIAM H. WILSON and BERNARD J. CARROLL, JR.

Department of Psychiatry, Duke University Medical Center Durham, North Carolina 27710

Address requests for reprints to: Dr. Ranga Rama Krishnan, Department of Psychiatry, Duke University Medical Center, Box 3215, Durham, North Carolina 27710.

The effects of the a-adrenergic agonist methoxamine on the human hypothalamic-pituitary-adrenal axis was assessed by a placebo-controlled study in the morning and one in the evening. A 5-mg iv bolus dose of methoxamine in normal subjects caused a significant rise in plasma ACTH and cortisol concentrations in the morning study. However, no significant change in plasma cortisol or ACTH concentrations was noted during the evening study. These studies suggest the existence of a diurnal variation in {alpha}1-adrenergic regulation of the hypothalamic- pituitary-adrenal axis.

Received July 16, 1987.




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Copyright © 1988 by The Endocrine Society