This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by YAMAJI, T. Articles by FUKUSHIMA, T. Search for Related Content PubMed PubMed Citation Articles by YAMAJI, T. Articles by FUKUSHIMA, T.

Plasma Levels of Atrial Natriuretic Hormone in Cushing’s Syndrome^*

Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo Hongo, Tokyo, Japan
The Fourth Department of Internal Medicine (A.I., S.K., J.I.), Saitama Medical School Iruma-gun, Saitama, Japan
The Department of Neurosurgery (M. T, T.F.), Mitsui Memorial Hospital Kanda, Tokyo, Japan

Address requests for reprints to: Tohru Yamaji, M.D., Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan.

To examine a possible role for atrial natriuretic hormone (ANH) in the water and electrolyte disturbances associated with hypercortisolism, plasma ANH levels were measured in 18 patients with endogenous Cushing’s syndrome. Nine patients had elevated plasma ANH levels compared to normal subjects. The mean plasma ANH concentration [72.5 ± 13.0 (±SE) pg/mL (23.5 ± 4.2 pmol/L)] in the Cushing’s syndrome patients was significantly higher than that in 40 normal subjects [37.6 ± 1.9 pg/mL (12.2 ± 0.62 pmol/L)]. A significant positive correlation was found between plasma ANH and cortisol levels in individual patients. There were no significant correlations, on the other hand, between plasma ANH concentrations and PRA, plasma aldosterone levels, or mean blood pressure. After treatment, plasma ANH concentrations decreased in all 6 patients who had elevated plasma ANH levels preoperatively. In 1 patient with Cushing’s disease, plasma ANH levels changed in parallel with plasma cortisol concentrations during o.p’DDD treatment. Fifteen patients who were receiving long term synthetic glucocorticoid therapy for the treatment of miscellaneous diseases had a significantly higher mean plasma ANH level [50.2 ± 4.0 (±SE) pg/mL (16.3 ± 1.3 pmol/L)] than that in normal subjects. These results suggest that plasma ANH levels are elevated in a substantial number of patients with Cushing’s syndrome due to either a direct stimulatory effect of glucocorticoid on atrial ANH secretion or, alternatively, intravascular volume expansion resulting from excessive cortisol secretion.

^* This work was supported in part by a Grant-in-Aid for Scientific Research (61480248) from the Ministry of Education, Science, and Culture and a research grant from the Ministry of Health and Welfare, Disorders of Adrenal Hormone Research Committee, Japan.

Received October 19, 1987.

This article has been cited by other articles:

				C. Sala, B. Ambrosi, and A. Morganti Blunted Vascular and Renal Effects of Exogenous Atrial Natriuretic Peptide in Patients with Cushing's Disease J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 1957 - 1961. [Abstract] [Full Text]