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Journal of Clinical Endocrinology & Metabolism Vol. 67, No. 1 191-193
doi:10.1210/jcem-67-1-191
Copyright © 1988 by the Endocrine Society.
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Normal Response of Factor VIII and von Willebrand Factor to 1-Deamino-8D-Arginine Vasopressin in Nephrogenic Diabetes Insipidus

B. BRENNER, U. SELIGSOHN and Z. HOCHBERG

Institute of Hematology (B.B.) and Division of Pediatric Endocrinology (Z.H.), Rambam Medical Center Haifa
The Institute of Hematology, Tel Aviv Medical Center (U.S.), and Sackler Faculty of Medicine Tel Aviv, Israel

Address requests for reprints to : Dr. Z. Hochberg, Department of Pharmacology, Rappaport Family Institute, P.O. 9697, Haifa 31096, Israel.

The effects of l-deamino-8D-arginine vasopressin (DDAVP) on plasma factor VIII and von Willebrand factor (vWF) levels were studied in four patients with nephrogenic diabetes insipidus (NDI) from two unrelated families. While the urine osmolality remained low, the plasma levels of factor VIII and vWF rose 2- to 3-fold after infusion of 0.3 µg/kg DDAVP, compared to preinfusion levels. The degree of increase was similar in both NDI patients and normal subjects. We conclude that in NDI patients the end-organ resistance to DDAVP is confined to the kidneys and does not involve the sites from which factor VIII and vWF are released.

Received October 15, 1987.




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Copyright © 1988 by The Endocrine Society