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DIVERGENT CORRELATIONS OF CIRCULATING DEHYDROEPIANDROSTERONE SULFATE AND TESTOSTERONE WITH INSULIN LEVELS AND INSULIN RECEPTOR BINDING.

Depts. of Ob/Gyn and Medicine and Clinical Research Center, The University of Tennessee Memphis, TN 38163

We evaluated the insulin response to a standard oral glucose tolerance test (OGTT) and in vitro insulin binding to erythrocytes (RBC) in 26 women from 3 groups: Group NW, normal women (n=11); Group DS, women (n=9) with elevated serum DHEAS concentrations, >400 µg/dl (>10.84 µmol/L); and Group IR, women (n=6) with elevated basal plasma insulin concentrations (IRI). There was a significant linear correlation between the area under the insulin response curve (IRI-AUC) and serum testosterone (T) (r=0.78, p=0.0001). Using stepwise multiple linear regression, IRI-AUC was characterized as a function of both serum T and DHEAS; positively with T and negatively with DHEAS. In vitro (n=17), there was a positive correlation between RBC-insulin binding and serum DHEAS (r=0.54, p=0.029) and a negative correlation between RBC-binding and T (r=–0.57, p=0.017). We conclude that DHEAS may enhance insulin binding and action and that DHEAS and T have divergent functional relationships with IRI. DHEAS and T may therefore exert opposing effects on insulin secretion and action.

Received February 3, 1988.

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