help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ahonen, P.
Right arrow Articles by Perheentupa, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ahonen, P.
Right arrow Articles by Perheentupa, J.

Journal of Clinical Endocrinology & Metabolism, Vol 66, 1152-1157, Copyright © 1988 by Endocrine Society


ARTICLES

The expression of autoimmune polyglandular disease type I appears associated with several HLA-A antigens but not with HLA-DR

P Ahonen, S Koskimies, ML Lokki, A Tiilikainen and J Perheentupa
Children's Hospital, University of Helsinki, Finland.

We studied HLA-A, -B, -C, and -DR antigens in 45 patients (from among 34 families), aged 10.2-60 yr, with polyglandular autoimmune disease type I (APG I) and in other family members. HLA-A28 was more frequent in the patients (25%) than in unaffected siblings (16%; P less than 0.05) or in normal Finnish subjects (8.8%; P less than 0.005, corrected P less than 0.2). Compared with the normal subjects, HLA-A28 was more frequent in the patients with hypoparathyroidism (31%; P less than 0.001, corrected P less than 0.04), adrenocortical failure (27%; P less than 0.01), insulin-dependent diabetes mellitus (IDDM; 66%; P less than 0.01), keratopathy (53%; P less than 0.001, corrected P less than 0.04), and alopecia (40%; P less than 0.001, corrected P less than 0.04), but not in the patients with ovarian failure (9%; P = NS). HLA- A28 was more frequent in the patients with hypoparathyroidism (31%) than in APG I patients without it (13%; P less than 0.005, corrected P less than 0.2). It was also more frequent in the patients with IDDM (66%) than in those without it (21%; P less than 0.05). HLA-A3 was more frequent in the patients with ovarian failure (82%) than in APG I patients with normal ovarian function (22%; P less than 0.025) and in normal subjects (45.5%; P less than 0.05). HLA-A9 was less frequent in the patients with ovarian failure (0%) than in those with normal ovarian function (55%; P less than 0.005, corrected P less than 0.2), and it was less frequent (P less than 0.025) in the patients with adrenocortical failure than in those with normal adrenal function. No association was found with any single DR antigen, but of 4 DR-typed IDDM patients, 3 were DR3 or DR4 positive (P = NS). The occurrence of adrenocortical failure, but not hypoparathyroidism, was familial and associated with HLA haploidentity among sets of affected siblings.


This article has been cited by other articles:


Home page
Hum Reprod UpdateHome page
R. Cervera and J. Balasch
Bidirectional effects on autoimmunity and reproduction
Hum. Reprod. Update, May 22, 2008; (2008) dmn013v1.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
S. Hassler, C. Ramsey, M. C. Karlsson, D. Larsson, B. Herrmann, B. Rozell, M. Backheden, L. Peltonen, O. Kampe, and O. Winqvist
Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma
Blood, September 15, 2006; 108(6): 1941 - 1948.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
C. Betterle, C. Dal Pra, F. Mantero, and R. Zanchetta
Autoimmune Adrenal Insufficiency and Autoimmune Polyendocrine Syndromes: Autoantibodies, Autoantigens, and Their Applicability in Diagnosis and Disease Prediction
Endocr. Rev., June 1, 2002; 23(3): 327 - 364.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
M. Halonen, P. Eskelin, A.-G. Myhre, J. Perheentupa, E. S. Husebye, O. Kampe, F. Rorsman, L. Peltonen, I. Ulmanen, and J. Partanen
AIRE Mutations and Human Leukocyte Antigen Genotypes as Determinants of the Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Phenotype
J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2568 - 2574.
[Abstract] [Full Text] [PDF]


Home page
Hum Mol GenetHome page
C. Ramsey, O. Winqvist, L. Puhakka, M. Halonen, A. Moro, O. Kampe, P. Eskelin, M. Pelto-Huikko, and L. Peltonen
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
Hum. Mol. Genet., February 1, 2002; 11(4): 397 - 409.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
F. Cetani, G. Barbesino, S. Borsari, E. Pardi, L. Cianferotti, A. Pinchera, and C. Marcocci
A Novel Mutation of the Autoimmune Regulator Gene in an Italian Kindred with Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy, Acting in a Dominant Fashion and Strongly Cosegregating with Hypothyroid Autoimmune Thyroiditis
J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4747 - 4752.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
L. Ward, J. Paquette, E. Seidman, C. Huot, F. Alvarez, P. Crock, E. Delvin, O. Kämpe, and C. Deal
Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy in an Adolescent Girl with a Novel AIRE Mutation: Response to Immunosuppressive Therapy
J. Clin. Endocrinol. Metab., March 1, 1999; 84(3): 844 - 852.
[Abstract] [Full Text]


Home page
J. Clin. Endocrinol. Metab.Home page
C. Betterle, N. A. Greggio, and M. Volpato
Autoimmune Polyglandular Syndrome Type 1
J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1049 - 1055.
[Full Text]


Home page
Endocr. Rev.Home page
A. Hoek, J. Schoemaker, and H. A. Drexhage
Premature Ovarian Failure and Ovarian Autoimmunity
Endocr. Rev., February 1, 1997; 18(1): 107 - 134.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1988 by The Endocrine Society