This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by REEVE, J. Articles by MEUNIER, P. J. Search for Related Content PubMed PubMed Citation Articles by REEVE, J. Articles by MEUNIER, P. J.

Skeletal Blood Flow, Iliac Histomorphometry, and Strontium Kinetics in Osteoporosis: A Relationship Between Blood Flow and Corrected Apposition Rate

Medical Research Council Clinical Research Centre and Northwick Park Hospital Harrow, HA1 3UJ United Kingdom
Unité Inserm 234, Pathologie des Tissus Calcifiés, Uniuersité Claude Bernard (M.A., C.E., P.J.M.) Lyon, France

Address requests for reprints to: Dr. J. Reeve, Clinical Research Centre, Bone Disease Research Group, Watford Road, Harrow, Middlesex, HA1 3UJ United Kingdom.

In 20 untreated patients with idiopathic or postmenopausal osteoporosis, kinetic studies of skeletal blood flow (using ¹⁸F) and bone turnover (using ⁸⁵Sr) were combined with dynamic histomorphometry performed on transiliac biopsies taken within 6 weeks of each other. In 8 patients the combined studies were repeated after treatment. A further 5 patients were studied only while receiving treatment. As expected, skeletal blood flow measured by ¹⁸F correlated with an index of ⁸⁵Sr uptake into the exchangeable pools of bone. Additionally and independently, skeletal blood flow correlated with an index of the work rate of the osteoblasts in each multicellular unit of bone (the corrected apposition rate of Parfitt). These correlations were statistically significant in both the untreated patients (P < 0.05) and the whole group (P < 0.001). Further indices related to bone turnover at the level of the skeleton as a whole were significantly associated with skeletal blood flow only in the combined group.

^* Current address: Department of Medical Physics, Royal Postgraduate Medical School, Ducane Road, London, W12 OHS United Kingdom.

Received August 24, 1987.

This article has been cited by other articles:

				K. Uchida, H. Nakajima, T. Miyazaki, T. Yayama, H. Kawahara, S. Kobayashi, T. Tsuchida, H. Okazawa, Y. Fujibayashi, and H. Baba Effects of Alendronate on Bone Metabolism in Glucocorticoid-Induced Osteoporosis Measured by 18F-Fluoride PET: A Prospective Study J. Nucl. Med., November 1, 2009; 50(11): 1808 - 1814. [Abstract] [Full Text] [PDF]

				T. L. Andersen, T. E. Sondergaard, K. E. Skorzynska, F. Dagnaes-Hansen, T. L. Plesner, E. M. Hauge, T. Plesner, and J.-M. Delaisse A Physical Mechanism for Coupling Bone Resorption and Formation in Adult Human Bone Am. J. Pathol., January 1, 2009; 174(1): 239 - 247. [Abstract] [Full Text] [PDF]

				D. M. Findlay Vascular pathology and osteoarthritis Rheumatology, December 1, 2007; 46(12): 1763 - 1768. [Abstract] [Full Text] [PDF]

				I. McCarthy The Physiology of Bone Blood Flow: A Review J. Bone Joint Surg. Am., November 1, 2006; 88(suppl_3): 4 - 9. [Abstract] [Full Text] [PDF]

				M. L. Yen, J. L. Su, C. L. Chien, K. W. Tseng, C. Y. Yang, W. F. Chen, C. C. Chang, and M. L. Kuo Diosgenin Induces Hypoxia-Inducible Factor-1 Activation and Angiogenesis through Estrogen Receptor-Related Phosphatidylinositol 3-kinase/Akt and p38 Mitogen-Activated Protein Kinase Pathways in Osteoblasts Mol. Pharmacol., October 1, 2005; 68(4): 1061 - 1073. [Abstract] [Full Text] [PDF]

				J. H. Thrall Quality and Safety Revolution in Health Care Radiology, October 1, 2004; 233(1): 3 - 6. [Full Text] [PDF]

				T. T.-F. Shih, H.-C. Liu, C.-J. Chang, S.-Y. Wei, L.-C. Shen, and P.-C. Yang Correlation of MR Lumbar Spine Bone Marrow Perfusion with Bone Mineral Density in Female Subjects Radiology, October 1, 2004; 233(1): 121 - 128. [Abstract] [Full Text] [PDF]

				T. T.-F. Shih, C.-J. Chang, W.-Y. I. Tseng, J.-K. Hsiao, L.-C. Shen, T.-W. Liu, and P.-C. Yang Effect of Calcium Channel Blockers on Vertebral Bone Marrow Perfusion of the Lumbar Spine Radiology, April 1, 2004; 231(1): 24 - 30. [Abstract] [Full Text] [PDF]

				A. Gurlek, M. R. Pittelkow, and R. Kumar Modulation of Growth Factor/Cytokine Synthesis and Signaling by 1{alpha},25-Dihydroxyvitamin D3: Implications in Cell Growth and Differentiation Endocr. Rev., December 1, 2002; 23(6): 763 - 786. [Abstract] [Full Text] [PDF]

				G. M. Blake, S.-J. Park-Holohan, and I. Fogelman Quantitative Studies of Bone in Postmenopausal Women Using 18F-Fluoride and 99mTc-Methylene Diphosphonate J. Nucl. Med., March 1, 2002; 43(3): 338 - 345. [Abstract] [Full Text] [PDF]

				M. Piert, T. T. Zittel, G. A. Becker, M. Jahn, A. Stahlschmidt, G. Maier, H.-J. Machulla, and R. Bares Assessment of Porcine Bone Metabolism by Dynamic [18F]Fluoride Ion PET: Correlation with Bone Histomorphometry J. Nucl. Med., July 1, 2001; 42(7): 1091 - 1100. [Abstract] [Full Text] [PDF]

				P. ESBRIT, M. V. ALVAREZ-ARROYO, F. DE MIGUEL, O. MARTIN, M. E. MARTINEZ, and C. CARAMELO C-Terminal Parathyroid Hormone-Related Protein Increases Vascular Endothelial Growth Factor in Human Osteoblastic Cells J. Am. Soc. Nephrol., June 1, 2000; 11(6): 1085 - 1092. [Abstract] [Full Text]

				D. S. Wang, M. Miura, H. Demura, and K. Sato Anabolic Effects of 1,25-Dihydroxyvitamin D3 on Osteoblasts Are Enhanced by Vascular Endothelial Growth Factor Produced by Osteoblasts and by Growth Factors Produced by Endothelial Cells Endocrinology, July 1, 1997; 138(7): 2953 - 2962. [Abstract] [Full Text] [PDF]