help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baethge, B. A.
Right arrow Articles by Wolf, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baethge, B. A.
Right arrow Articles by Wolf, R. E.

Journal of Clinical Endocrinology & Metabolism, Vol 66, 485-488, Copyright © 1988 by Endocrine Society

ARTICLES

Antibodies to nuclear antigens in Graves' disease

BA Baethge, SN Levine and RE Wolf
Section of Rheumatology, Louisiana State University Medical Center, Shreveport 71130.

A recent publication reported a high prevalence of double-stranded DNA antibodies quantitated by RIA in patients with Graves' disease. We, therefore, measured antibodies to a variety of nuclear antigens in 20 patients with Graves' disease, most of whom where hyperthyroid. Fluorescent antinuclear antibody tests using HEp-2 cells as substrate were positive in serum of 15 of the 20 patients but in only 2 of 20 normal subjects. DNA binding, determined by RIA, was increased in 12 of 18 patients with Graves' disease. However, a more specific indirect immunofluorescence assay for antibodies to double-stranded DNA using Crithidia luciliae was negative in all 20 patients. Furthermore, antibodies to single-stranded DNA, measured by counterimmunoelectrophoresis, and ribonucleoprotein and Sm antigens, measured by double diffusion in agar, were undetectable in all patients tested. These results demonstrate a high frequency of antinuclear antibody in patients with Graves' disease. The presence of antibodies to double-stranded DNA was not confirmed when assayed by the highly specific and sensitive Crithidia luciliae method, suggesting nonantibody DNA binding in the DNA RIA.


This article has been cited by other articles:


Home page
 LupusHome page
I Uthman, I Salti, and M Khamashta
Endocrinologic Manifestations of the Antiphospholipid Syndrome
Lupus, August 1, 2006; 15(8): 485 - 489.
[Abstract] [PDF]

Home page
 Ann Rheum DisHome page
M G Tektonidou, M Anapliotou, P Vlachoyiannopoulos, and H M Moutsopoulos
Presence of systemic autoimmune disorders in patients with autoimmune thyroid diseases
Ann Rheum Dis, September 1, 2004; 63(9): 1159 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
C-N Huang, T-C Hsu, H-H Chou, and G J Tsay
Anti-nuclear antibody, anti-DNA, and aCL in Graves' disease patients treated with propyluracil or methimazole
Lupus, June 1, 2004; 13(6): 450 - 454.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1988 by The Endocrine Society