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High Serum Progesterone in Hyperthyroid Men with Graves' Disease^*

Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical College Tokyo 162, Japan
Eiken ICL (H.S.) Tokyo 114, Japan

Address all correspondence and requests for reprints to: Dr. Kaoru Nomura, Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162, Japan.

We measured serum progesterone in five men with hyperthyroidism due to Graves' disease. All had elevated serum progesterone levels before treatment with an antithyroid drug, and their serum progesterone levels declined concomitantly with their serum thyroid levels during treatment. Progesterone enhances estrogen's stimulation of mammary gland growth, and our findings suggest that progesterone may play a role in the gynecomastia that occurs in men with hyperthyroidism.

^* This work was supported in part by a grant for the treatment of intractable diseases from the Japanese Ministry of Health and Welfare.

Received April 24, 1987.

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