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Effect of Human Atrial Natriuretic Peptide on 1 -Deamino-D-Arg⁸-Vasopressin-Induced Antidiuresis in Man^*

Division of Clinical Endocrinology and Diabetes Mellitus, I. Medizinische Uniuersitätsklinik Wien, Austria

Address all correspondence and requests for reprints to: Dr. H. Vierhapper, Division of Clinical Endocrinology and Diabetes Mellitus, I. Medizinische Universitäts Klinik, Lazarettgasse 14, A-1090 Wien,Austria.

The interaction of exogenous synthetic human atrial natriuretic peptide (hANP), given in iv bolus doses of 100, 200, and 400 µg, and of various bolus-primed infusions of 1-deamino-D-Arg⁸-vasopressin (dDAVP), a nonpressor analog of antidiuretic hormone, were investigated in six normal men. A marked dose-dependent rise in plasma hANP concentrations occurred after the administration of hANP. The antidiuretic effect of dDAVP (P < 0.01) was partially but not completely reversed by the concomitant administration of hANP (P < 0.01). hANP-induced natriuresis was similar in the presence and absence of dDAVP-induced antidiuresis. While these results do not prove that hANP-dependent natriuresis and diuresis are independent phenomena, it is of clinical interest that natriuresis without diuresis can be induced by the simultaneous administration of hANP and dDAVP.

^* This work was supported by the Fonds zur Förderung der wissenschaftlichen Forschung Österreichs (Grant P6539M).

Received June 17, 1987.