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Journal of Clinical Endocrinology & Metabolism, Vol 65, 1305-1307, Copyright © 1987 by Endocrine Society

ARTICLES

Potentiation of peptide histidine methionine (PHM) on corticotropin- releasing hormone (CRH) induced ACTH secretion in humans

A Sasaki, S Sato, M Go, O Murakami, K Hanew and K Yoshinaga
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

The effects of rat corticotropin-releasing hormone (CRH) and of synthetic peptide histidine methionine (PHM) on ACTH release were studied in vivo in humans. PHM alone did not alter the basal plasma ACTH or cortisol levels, but it strongly potentiated CRH-induced ACTH secretion. These results, together with our previous observation that PHM immunoreactivity is present in human hypothalamus and pituitary stalk, suggest that PHM may play a physiological role in the regulation of ACTH secretion in humans.




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Copyright © 1987 by The Endocrine Society