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Journal of Clinical Endocrinology & Metabolism, Vol 65, 1095-1097, Copyright © 1987 by Endocrine Society

ARTICLES

Effect of posture on clearance of atrial natriuretic peptide from plasma

AH Gillies, IG Crozier, MG Nicholls, EA Espiner and TG Yandle
Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand.

The effect of posture on plasma atrial natriuretic peptide (ANP) levels during a constant iv infusion of the 28-amino acid polypeptide was investigated in 8 normal men. alpha-Human ANP was infused at a constant rate of 0.5 micrograms/min (162 pmol/min) while the men were supine, then erect, and finally when supine again. Plasma ANP levels rose from 10.9 +/- 1.6 (+/- SEM) to 33.3 +/- 2.4 pmol/L after 60 min of constant infusion with the men in the supine position. On standing, plasma ANP increased further to 40.6 +/- 3.4 pmol/L, then fell to 32.2 +/- 2.7 pmol/L with resumption of supine posture. The calculated MCR of ANP fell from a mean of 7.7 to 5.7 L/min on standing, but rose again to 7.6 L/min upon lying down. We conclude that body posture has a significant effect on the rate of clearance of ANP from plasma.




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Copyright © 1987 by The Endocrine Society