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Plasma Lipoproteins and Lipase and LecithinrCholesterol Acyltransferase Activities in Obese Subjects Before and After Weight Reduction

Iphar-Institute for Clinical Pharmacology Munich West Germany

Address request for reprints to: Dr. Peter Weisweiler, Assoc. Prof., MD, Iphar-Institute for Clinical Pharmacology Munich, P.O. Box 1165, 8011 Höhenkirchen-Siegertsbrunn, West Germany.

Plasma lipoprotein concentrations and postheparin lipoprotein lipase, hepatic triglyceride lipase (HTGL), and lecithinxholesterol acyltransferase (LCAT) activities were determined in 10 obese women before and after weight loss. In period I, a diet was given to maintain constant weight for 3 weeks. In period II, total calories were restricted to 600 kilocalories/day for 3 weeks. In period III, caloric intake was adjusted to maintain weight at the lower level for 6 weeks. The lower calorie diet decreased plasma very low density, low density, and high density lipoprotein (HDL), cholesterol, and apolipoprotein B and A-I concentrations and molar enzyme activities, while the percent conversion of free to esterified cholesterol by the LCAT enzyme was unchanged. During weight stabilization at a lower state (period III), the mean plasma HDL cholesterol level increased, and lipoprotein lipase and LCAT activities increased to values higher than those in period I. The mean HTGL activity remained reduced. I conclude that successful weight loss improves the possibly atherogenic plasma lipoprotein profile of obese subjects. The increase in HDL cholesterol and cholesterol esterification, possibly explained by lowered HTGL enzyme activity, may increase the capacity of HDL to transport cholesterol from peripheral cells to the liver.

Received March 31, 1987.

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