Journal of Clinical Endocrinology & Metabolism, Vol 65, 969-973, Copyright © 1987 by Endocrine Society

ARTICLES

Plasma lipoproteins and lipase and lecithin:cholesterol acyltransferase activities in obese subjects before and after weight reduction

P Weisweiler
Iphar-Institute for Clinical Pharmacology Munich, West Germany.

Plasma lipoprotein concentrations and post-heparin lipoprotein lipase, hepatic triglyceride lipase (HTGL), and lecithin:cholesterol acyltransferase (LCAT) activities were determined in 10 obese women before and after weight loss. In period I, a diet was given to maintain constant weight for 3 weeks. In period II, total calories were restricted to 600 kilocalories/day for 3 weeks. In period III, caloric intake was adjusted to maintain weight at the lower level for 6 weeks. The lower calorie diet decreased plasma very low density, low density, and high density lipoprotein (HDL), cholesterol, and apolipoprotein B and A-I concentrations and molar enzyme activities, while the percent conversion of free to esterified cholesterol by the LCAT enzyme was unchanged. During weight stabilization at a lower state (period III), the mean plasma HDL cholesterol level increased, and lipoprotein lipase and LCAT activities increased to values higher than those in period I. The mean HTGL activity remained reduced. I conclude that successful weight loss improves the possibly atherogenic plasma lipoprotein profile of obese subjects. The increase in HDL cholesterol and cholesterol esterification, possibly explained by lowered HTGL enzyme activity, may increase the capacity of HDL to transport cholesterol from peripheral cells to the liver.

This article has been cited by other articles:

				I. M. Singh, M. H. Shishehbor, and B. J. Ansell High-Density Lipoprotein as a Therapeutic Target: A Systematic Review JAMA, August 15, 2007; 298(7): 786 - 798. [Abstract] [Full Text] [PDF]

				M. D. Ashen and R. S. Blumenthal Low HDL Cholesterol Levels N. Engl. J. Med., September 22, 2005; 353(12): 1252 - 1260. [Full Text] [PDF]

				K. P. Truesdale, J. Stevens, and J. Cai The Effect of Weight History on Glucose and Lipids: The Atherosclerosis Risk in Communities Study Am. J. Epidemiol., June 15, 2005; 161(12): 1133 - 1143. [Abstract] [Full Text] [PDF]

				F. M. Riches, G. F. Watts, J. Hua, G. R. Stewart, R. P. Naoumova, and P. H. R. Barrett Reduction in Visceral Adipose Tissue Is Associated with Improvement in Apolipoprotein B-100 Metabolism in Obese Men J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2854 - 2861. [Abstract] [Full Text]