Journal of Clinical Endocrinology & Metabolism, Vol 65, 896-900, Copyright © 1987 by Endocrine Society

ARTICLES

Acute effect of glyburide on insulin sensitivity in type I diabetic patients

DR Garrel, R Picq, L Bajard, M Harfouche and J Tourniaire
Clinique Endocrinologique, Hopital de l'Antiquaille, Lyon, France.

Possible extrapancreatic effects of glyburide on insulin action were studied in six patients with insulin-dependent diabetes mellitus. Each patient was studied on two separate occasions with continuous iv infusions of either glyburide (0.3 mg/h after a 1-mg iv bolus dose) or NaCl. During the studies blood glucose concentrations were controlled by a glucose-controlled infusion system (Biostator). The study included the 12-h period after the evening meal, followed by a 4-h period during which euglycemic hyperinsulinemic clamp studies were performed at two rates of insulin infusion: 1 and 10 mU/kg.min. During the glyburide infusion, the Biostator-determined insulin delivery rate was similar to that during the NaCl infusion for the first 6 h after the meal, but it decreased by 32% between the 6th and 12th hours after the meal. During the hyperinsulinemic clamp studies, glucose was delivered at a significantly higher rate when glyburide was infused; this was true for both rates of insulin infusion [5.6 +/- 1.9 (+/- SD) vs. 3.6 +/- 1.4 mg/kg.min and 12.1 +/- 2.4 vs. 9.1 +/- 2.1 mg/kg.min; P less than 0.05, glyburide vs. NaCl, respectively]. Plasma C-peptide was undetectable in all patients during both studies. These results indicate that 1) glyburide has an acute effect on insulin action in insulin-dependent diabetic patients; and 2) this effect occurs at physiological as well as pharmacological insulin concentrations.

This article has been cited by other articles:

				M. U Kabadi and U. M Kabadi Efficacy of Sulfonylureas with Insulin in Type 2 Diabetes Mellitus Ann. Pharmacother., November 1, 2003; 37(11): 1572 - 1576. [Abstract] [Full Text] [PDF]